Effects of simvastatin, bezafibrate and gemfibrozil on the quantity and composition of plasma lipoproteins.

Article Details

Citation

Copy to clipboard

Nakandakare E, Garcia RC, Rocha JC, Sperotto G, Oliveira HC, Quintao EC

Effects of simvastatin, bezafibrate and gemfibrozil on the quantity and composition of plasma lipoproteins.

Atherosclerosis. 1990 Dec;85(2-3):211-7.

PubMed ID

2102085 [ View in PubMed

]

Abstract

Simvastatin, 10-40 mg/d (n = 11), bezafibrate, 600 mg/d (n = 6), and gemfibrozil, 1200 mg/d (n = 5) were administered for 12 weeks after a 4-week placebo period to subjects with initial plasma levels (mg/100 ml. mean +/- SD) of cholesterol (346 +/- 77), and of triglycerides (180 +/- 54). Total LDL-C plasma concentration was lowered 32% by simvastatin and 35% by bezafibrate, but only bezafibrate diminished the triglyceride (41%) and increased HDL-C plasma levels (35%). Plasma lipoprotein fractions obtained by discontinuous gradient ultracentrifugation, namely, VLDL, lighter LDL (LDL-1), heavier LDL (LDL-2) and bulk HDL were chemically analyzed. Simvastatin and bezafibrate significantly diminished the quantity of VLDL and LDL-1 particles, although barely modifying their composition. Neither drug influenced the LDL-2 plasma concentration. Bezafibrate increased the total plasma HDL level little interfering with its chemical composition. Gemfibrozil was the least effective of all drugs but decreased the lipid and protein contents and their ratios in VLDL and LDL-2.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Bezafibrate	Approved Investigational	VLDL phospholipids	decreased	Bezafibrate decreases the level of VLDL phospholipids in the blood
Bezafibrate	Approved Investigational	LDL1 cholesterol	decreased	Bezafibrate decreases the level of LDL1 cholesterol in the blood
Bezafibrate	Approved Investigational	LDL1 triglycerides	decreased	Bezafibrate decreases the level of LDL1 triglycerides in the blood
Simvastatin	Approved	VLDL cholesterol	decreased	Simvastatin decreases the level of VLDL cholesterol in the blood
Simvastatin	Approved	VLDL triglycerides	decreased	Simvastatin decreases the level of VLDL triglycerides in the blood
Simvastatin	Approved	VLDL phospholipids	decreased	Simvastatin decreases the level of VLDL phospholipids in the blood
Bezafibrate	Approved Investigational	HDL triglycerides	increased	Bezafibrate increases the level of HDL triglycerides in the blood
Bezafibrate	Approved Investigational	HDL phospholipids	increased	Bezafibrate increases the level of HDL phospholipids in the blood
Simvastatin	Approved	HDL triglycerides	increased	Simvastatin increases the level of HDL triglycerides in the blood
Gemfibrozil	Approved	VLDL phospholipids	decreased	Gemfibrozil decreases the level of VLDL phospholipids in the blood
Gemfibrozil	Approved	LDL2 triglycerides	decreased	Gemfibrozil decreases the level of LDL2 triglycerides in the blood
Gemfibrozil	Approved	LDL2 phospholipids	decreased	Gemfibrozil decreases the level of LDL2 phospholipids in the blood
Bezafibrate	Approved Investigational	VLDL cholesterol	decreased	Bezafibrate decreases the level of VLDL cholesterol in the blood
Gemfibrozil	Approved	VLDL cholesterol	decreased	Gemfibrozil decreases the level of VLDL cholesterol in the blood
Gemfibrozil	Approved	VLDL triglycerides	decreased	Gemfibrozil decreases the level of VLDL triglycerides in the blood
Bezafibrate	Approved Investigational	HDL cholesterol	increased	Bezafibrate increases the level of HDL cholesterol in the blood
Bezafibrate	Approved Investigational	LDL cholesterol	decreased	Bezafibrate decreases the level of LDL cholesterol in the blood
Bezafibrate	Approved Investigational	VLDL triglycerides	decreased	Bezafibrate decreases the level of VLDL triglycerides in the blood
Simvastatin	Approved	Total cholesterol	decreased	Simvastatin decreases the level of Total cholesterol in the blood
Bezafibrate	Approved Investigational	Total cholesterol	decreased	Bezafibrate decreases the level of Total cholesterol in the blood
Gemfibrozil	Approved	Triglycerides	decreased	Gemfibrozil decreases the level of Triglycerides in the blood
Bezafibrate	Approved Investigational	Triglycerides	decreased	Bezafibrate decreases the level of Triglycerides in the blood
Simvastatin	Approved	LDL cholesterol	decreased	Simvastatin decreases the level of LDL cholesterol in the blood