alpha 1-antagonists in the treatment of hypertension.
Article Details
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Grimm RH Jr
alpha 1-antagonists in the treatment of hypertension.
Hypertension. 1989 May;13(5 Suppl):I131-6.
- PubMed ID
- 2577457 [ View in PubMed]
- Abstract
A number of agents are now available to treat hypertension. One relatively new class of agents is the selective alpha 1-inhibitors, which have distinct advantages over earlier nonselective alpha-adrenergic receptor-blocking agents. Three alpha 1-inhibitors are reviewed in this article: prazosin, terazosin, and doxazosin. These alpha 1-inhibitors are similar in chemical structure and pharmacological action. alpha 1-Inhibitors lower blood pressure by reducing vascular tone in resistance and capacitance vessels. alpha 1-Inhibitors are similar in effectiveness in blood pressure lowering to other commonly used antihypertensive agents like the thiazide diuretic drugs and beta-blockers, which are efficacious as monotherapy in lowering pressure, as initial agents, or in combination with other antihypertensive agents in multidrug therapeutic regimens. alpha 1-Inhibitors are associated with a reasonably low incidence of serious adverse effects and are essentially free of any adverse metabolic effects. alpha 1-Inhibitors have been shown to beneficially effect blood lipids in several studies. The favorable lipid effect makes alpha 1-inhibitors especially appropriate to use in diabetic hypertensive and other patients with elevated serum lipid levels. The beneficial lipid effects may enhance the ability of alpha 1-inhibitors to prevent coronary heart disease, an outcome that has been difficult to demonstrate in thiazide-based trials.
DrugBank Data that Cites this Article
- Pharmaco-metabolomics
Drug Drug Groups Metabolite Change Description Doxazosin Approved Cholesterol decreased Doxazosin decreases the level of Cholesterol in the blood Terazosin Approved Cholesterol decreased Terazosin decreases the level of Cholesterol in the blood Doxazosin Approved LDL cholesterol decreased Doxazosin decreases the level of LDL cholesterol in the blood Terazosin Approved LDL cholesterol decreased Terazosin decreases the level of LDL cholesterol in the blood Terazosin Approved HDL cholesterol increased Terazosin increases the level of HDL cholesterol in the blood Terazosin Approved Triglycerides decreased Terazosin decreases the level of Triglycerides in the blood Doxazosin Approved HDL cholesterol increased Doxazosin increases the level of HDL cholesterol in the blood Doxazosin Approved Triglycerides decreased Doxazosin decreases the level of Triglycerides in the blood