Fluvoxamine in the treatment of anxiety disorders.

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Irons J

Fluvoxamine in the treatment of anxiety disorders.

Neuropsychiatr Dis Treat. 2005 Dec;1(4):289-99.

PubMed ID

18568110 [ View in PubMed

]

Abstract

Fluvoxamine is a selective-serotonin reuptake inhibitor (SSRI) that has proved effective in large double-blind, randomized, controlled trials involving patients with social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), and panic disorder. Improvements have also been demonstrated in patients with post-traumatic stress disorder, as well as those with a range of obsessive-compulsive spectrum disorders including binge eating disorder, bulimia nervosa, pathological gambling, and body dysmorphic disorder. Several well controlled studies have confirmed the efficacy of fluvoxamine in children and adolescents with OCD, SAD, and other anxiety disorders, and it was the first SSRI to be registered for the treatment of OCD in children. Fluvoxamine is well tolerated. In common with other SSRIs, the most frequently reported adverse event is nausea. Fluvoxamine does not cause sedation or cognitive impairment and is associated with a low risk of sexual dysfunction, suicidality, and withdrawal reactions. It is safe in overdose and has no significant effect on body weight or cardiovascular parameters.

DrugBank Data that Cites this Article

Drugs

Fluvoxamine

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Fluvoxamine	Sodium-dependent serotonin transporter	Protein	Humans	Yes	Inhibitor	Details