Health Functionalities of Betaine in Patients With Homocystinuria.

Article Details

Citation

Truitt C, Hoff WD, Deole R

Health Functionalities of Betaine in Patients With Homocystinuria.

Front Nutr. 2021 Sep 9;8:690359. doi: 10.3389/fnut.2021.690359. eCollection 2021.

PubMed ID
34568401 [ View in PubMed
]
Abstract

Homocystinuria is a medical condition that can have widespread and harmful effects on multiple organ systems within the body. This disease is caused by a deficiency in one of the enzymes involved in the methionine metabolism pathway. One example would be a deficiency in cystathionine-beta-synthase (CBS), which is seen in classical homocystinuria. A deficiency in CBS can lead to elevated levels of homocysteine (HCY) and possible depletion of methionine and/or cysteine. There are several different treatment options for patients with this condition, one of which is the administration of the drug betaine. Here we review the use of betaine to decrease these elevated levels of homocysteine back to within normal ranges. Published literature indicates that the use of this choline derivative is most beneficial to patients who are either not compliant with the recommended low methionine and low protein diet or wish to consume a less restricted diet.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
BetaineBetaine--homocysteine S-methyltransferase 1ProteinHumans
Yes
Substrate
Details
Drug Reactions
Reaction
Details