Tibolone versus four estrogen replacement therapy protocols and plasma lipid levels in postmenopausal women.
Article Details
- CitationCopy to clipboard
Cetinkaya MB, Alper T, Kokcu A, Yanik FF, Malatyalioglu E
Tibolone versus four estrogen replacement therapy protocols and plasma lipid levels in postmenopausal women.
Int J Gynaecol Obstet. 2002 Oct;79(1):17-23.
- PubMed ID
- 12399086 [ View in PubMed]
- Abstract
OBJECTIVES: To compare tibolone therapy with four different estrogen replacement therapy protocols, with regard to the effects on plasma lipid profiles. METHODS: The plasma lipid levels of 178 postmenopausal women in five different therapy groups were compared with each other as well as their baseline levels with 6-month intervals during 2-year follow-up. Student's t-test, paired t-test and Pearson correlation analysis were utilized for statistical analysis. RESULTS: HDL cholesterol levels increased significantly from baseline in groups using oral estrogen (P<0.05) but a slight non-significant decrease was seen in tibolone therapy (P>0.05). LDL cholesterol levels significantly decreased at the end of the second year in oral estrogen and tibolone users (P<0.05). Triglyceride levels increased non-significantly with estrogen therapy (P>0.05), whilst decreased significantly in the tibolone group (P<0.05). CONCLUSION: Tibolone may be a good alternative to estrogen replacement therapy in postmenopausal women, as it has beneficial effects on LDL cholesterol and triglyceride levels, which play important role in atherosclerosis.
DrugBank Data that Cites this Article
- Pharmaco-metabolomics
Drug Drug Groups Metabolite Change Description Tibolone Approved Investigational LDL cholesterol decreased Tibolone decreases the level of LDL cholesterol in the blood Estradiol Approved Investigational Vet Approved HDL cholesterol increased Estradiol increases the level of HDL cholesterol in the blood Tibolone Approved Investigational Triglycerides decreased Tibolone decreases the level of Triglycerides in the blood