Tibolone versus four estrogen replacement therapy protocols and plasma lipid levels in postmenopausal women.

Article Details

Citation

Cetinkaya MB, Alper T, Kokcu A, Yanik FF, Malatyalioglu E

Tibolone versus four estrogen replacement therapy protocols and plasma lipid levels in postmenopausal women.

Int J Gynaecol Obstet. 2002 Oct;79(1):17-23.

PubMed ID
12399086 [ View in PubMed
]
Abstract

OBJECTIVES: To compare tibolone therapy with four different estrogen replacement therapy protocols, with regard to the effects on plasma lipid profiles. METHODS: The plasma lipid levels of 178 postmenopausal women in five different therapy groups were compared with each other as well as their baseline levels with 6-month intervals during 2-year follow-up. Student's t-test, paired t-test and Pearson correlation analysis were utilized for statistical analysis. RESULTS: HDL cholesterol levels increased significantly from baseline in groups using oral estrogen (P<0.05) but a slight non-significant decrease was seen in tibolone therapy (P>0.05). LDL cholesterol levels significantly decreased at the end of the second year in oral estrogen and tibolone users (P<0.05). Triglyceride levels increased non-significantly with estrogen therapy (P>0.05), whilst decreased significantly in the tibolone group (P<0.05). CONCLUSION: Tibolone may be a good alternative to estrogen replacement therapy in postmenopausal women, as it has beneficial effects on LDL cholesterol and triglyceride levels, which play important role in atherosclerosis.

DrugBank Data that Cites this Article

Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
TiboloneApproved InvestigationalLDL cholesterol
decreased
Tibolone decreases the level of LDL cholesterol in the blood
EstradiolApproved Investigational Vet ApprovedHDL cholesterol
increased
Estradiol increases the level of HDL cholesterol in the blood
TiboloneApproved InvestigationalTriglycerides
decreased
Tibolone decreases the level of Triglycerides in the blood