A review of drug-induced hyponatremia.

Article Details

Citation

Liamis G, Milionis H, Elisaf M

A review of drug-induced hyponatremia.

Am J Kidney Dis. 2008 Jul;52(1):144-53. doi: 10.1053/j.ajkd.2008.03.004. Epub 2008 May 12.

PubMed ID
18468754 [ View in PubMed
]
Abstract

Hyponatremia (defined as a serum sodium level < 134 mmol/L) is the most common electrolyte abnormality in hospitalized patients. Certain drugs (eg, diuretics, antidepressants, and antiepileptics) have been implicated as established causes of either asymptomatic or symptomatic hyponatremia. However, hyponatremia occasionally may develop in the course of treatment with drugs used in everyday clinical practice (eg, newer antihypertensive agents, antibiotics, and proton pump inhibitors). Physicians may not always give proper attention in time to undesirable drug-induced hyponatremia. Effective clinical management can be handled through awareness of the adverse effect of certain pharmaceutical compounds on serum sodium levels. Here, we review clinical information about the incidence of hyponatremia associated with specific drug treatment and discuss the underlying pathophysiologic mechanisms.

DrugBank Data that Cites this Article

Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
CyclophosphamideApproved InvestigationalSodium
decreased
Cyclophosphamide decreases the level of Sodium in the blood
MelphalanApprovedSodium
decreased
Melphalan decreases the level of Sodium in the blood
IfosfamideApprovedSodium
decreased
Ifosfamide decreases the level of Sodium in the blood
IndapamideApprovedSodium
decreased
Indapamide decreases the level of Sodium in the blood
LamotrigineApproved InvestigationalSodium
decreased
Lamotrigine decreases the level of Sodium in the blood
MethotrexateApprovedSodium
decreased
Methotrexate decreases the level of Sodium in the blood
LevamisoleApproved Investigational Vet Approved WithdrawnSodium
decreased
Levamisole decreases the level of Sodium in the blood
PentostatinApproved InvestigationalSodium
decreased
Pentostatin decreases the level of Sodium in the blood
ThioridazineApproved WithdrawnSodium
decreased
Thioridazine decreases the level of Sodium in the blood
TrifluoperazineApproved InvestigationalSodium
decreased
Trifluoperazine decreases the level of Sodium in the blood
CisplatinApprovedSodium
decreased
Cisplatin decreases the level of Sodium in the blood
CarboplatinApprovedSodium
decreased
Carboplatin decreases the level of Sodium in the blood
Valproic acidApproved InvestigationalSodium
decreased
Valproic acid decreases the level of Sodium in the blood
ProtriptylineApprovedSodium
decreased
Protriptyline decreases the level of Sodium in the blood
DesipramineApproved InvestigationalSodium
decreased
Desipramine decreases the level of Sodium in the blood
VenlafaxineApprovedSodium
decreased
Venlafaxine decreases the level of Sodium in the blood
VincristineApproved InvestigationalSodium
decreased
Vincristine decreases the level of Sodium in the blood
VinblastineApprovedSodium
decreased
Vinblastine decreases the level of Sodium in the blood
HaloperidolApprovedSodium
decreased
Haloperidol decreases the level of Sodium in the blood
CyclophosphamideApproved InvestigationalAntidiuretic hormone
increased
Cyclophosphamide increases the level of Antidiuretic hormone in the blood
MelphalanApprovedAntidiuretic hormone
increased
Melphalan increases the level of Antidiuretic hormone in the blood
IfosfamideApprovedAntidiuretic hormone
increased
Ifosfamide increases the level of Antidiuretic hormone in the blood
MethotrexateApprovedAntidiuretic hormone
increased
Methotrexate increases the level of Antidiuretic hormone in the blood
LevamisoleApproved Investigational Vet Approved WithdrawnAntidiuretic hormone
increased
Levamisole increases the level of Antidiuretic hormone in the blood
PentostatinApproved InvestigationalAntidiuretic hormone
increased
Pentostatin increases the level of Antidiuretic hormone in the blood
OxcarbazepineApprovedAntidiuretic hormone
increased
Oxcarbazepine increases the level of Antidiuretic hormone in the blood
ThioridazineApproved WithdrawnAntidiuretic hormone
increased
Thioridazine increases the level of Antidiuretic hormone in the blood
TrifluoperazineApproved InvestigationalAntidiuretic hormone
increased
Trifluoperazine increases the level of Antidiuretic hormone in the blood
CisplatinApprovedAntidiuretic hormone
increased
Cisplatin increases the level of Antidiuretic hormone in the blood
CarboplatinApprovedAntidiuretic hormone
increased
Carboplatin increases the level of Antidiuretic hormone in the blood
Valproic acidApproved InvestigationalAntidiuretic hormone
increased
Valproic acid increases the level of Antidiuretic hormone in the blood
ProtriptylineApprovedAntidiuretic hormone
increased
Protriptyline increases the level of Antidiuretic hormone in the blood
DesipramineApproved InvestigationalAntidiuretic hormone
increased
Desipramine increases the level of Antidiuretic hormone in the blood
VincristineApproved InvestigationalSodium
decreased
Vincristine decreases the level of Sodium in the blood
VinblastineApprovedSodium
decreased
Vinblastine decreases the level of Sodium in the blood
HaloperidolApprovedSodium
decreased
Haloperidol decreases the level of Sodium in the blood
CarbamazepineApproved InvestigationalSodium
decreased
Carbamazepine decreases the level of Sodium in the blood
AmilorideApprovedSodium
decreased
Amiloride decreases the level of Sodium in the blood
ChlorpropamideApproved InvestigationalSodium
decreased
Chlorpropamide decreases the level of Sodium in the blood
OxcarbazepineApprovedSodium
decreased
Oxcarbazepine decreases the level of Sodium in the blood
OxcarbazepineApprovedSodium
decreased
Oxcarbazepine decreases the level of Sodium in the blood
CarbamazepineApproved InvestigationalAntidiuretic hormone
increased
Carbamazepine increases the level of Antidiuretic hormone in the blood