A review of drug-induced hyponatremia.
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Liamis G, Milionis H, Elisaf M
A review of drug-induced hyponatremia.
Am J Kidney Dis. 2008 Jul;52(1):144-53. doi: 10.1053/j.ajkd.2008.03.004. Epub 2008 May 12.
- PubMed ID
- 18468754 [ View in PubMed]
- Abstract
Hyponatremia (defined as a serum sodium level < 134 mmol/L) is the most common electrolyte abnormality in hospitalized patients. Certain drugs (eg, diuretics, antidepressants, and antiepileptics) have been implicated as established causes of either asymptomatic or symptomatic hyponatremia. However, hyponatremia occasionally may develop in the course of treatment with drugs used in everyday clinical practice (eg, newer antihypertensive agents, antibiotics, and proton pump inhibitors). Physicians may not always give proper attention in time to undesirable drug-induced hyponatremia. Effective clinical management can be handled through awareness of the adverse effect of certain pharmaceutical compounds on serum sodium levels. Here, we review clinical information about the incidence of hyponatremia associated with specific drug treatment and discuss the underlying pathophysiologic mechanisms.
DrugBank Data that Cites this Article
- Pharmaco-metabolomics
Drug Drug Groups Metabolite Change Description Cyclophosphamide Approved Investigational Sodium decreased Cyclophosphamide decreases the level of Sodium in the blood Melphalan Approved Sodium decreased Melphalan decreases the level of Sodium in the blood Ifosfamide Approved Sodium decreased Ifosfamide decreases the level of Sodium in the blood Indapamide Approved Sodium decreased Indapamide decreases the level of Sodium in the blood Lamotrigine Approved Investigational Sodium decreased Lamotrigine decreases the level of Sodium in the blood Methotrexate Approved Sodium decreased Methotrexate decreases the level of Sodium in the blood Levamisole Approved Investigational Vet Approved Withdrawn Sodium decreased Levamisole decreases the level of Sodium in the blood Pentostatin Approved Investigational Sodium decreased Pentostatin decreases the level of Sodium in the blood Thioridazine Approved Withdrawn Sodium decreased Thioridazine decreases the level of Sodium in the blood Trifluoperazine Approved Investigational Sodium decreased Trifluoperazine decreases the level of Sodium in the blood Cisplatin Approved Sodium decreased Cisplatin decreases the level of Sodium in the blood Carboplatin Approved Sodium decreased Carboplatin decreases the level of Sodium in the blood Valproic acid Approved Investigational Sodium decreased Valproic acid decreases the level of Sodium in the blood Protriptyline Approved Sodium decreased Protriptyline decreases the level of Sodium in the blood Desipramine Approved Investigational Sodium decreased Desipramine decreases the level of Sodium in the blood Venlafaxine Approved Sodium decreased Venlafaxine decreases the level of Sodium in the blood Vincristine Approved Investigational Sodium decreased Vincristine decreases the level of Sodium in the blood Vinblastine Approved Sodium decreased Vinblastine decreases the level of Sodium in the blood Haloperidol Approved Sodium decreased Haloperidol decreases the level of Sodium in the blood Cyclophosphamide Approved Investigational Antidiuretic hormone increased Cyclophosphamide increases the level of Antidiuretic hormone in the blood Melphalan Approved Antidiuretic hormone increased Melphalan increases the level of Antidiuretic hormone in the blood Ifosfamide Approved Antidiuretic hormone increased Ifosfamide increases the level of Antidiuretic hormone in the blood Methotrexate Approved Antidiuretic hormone increased Methotrexate increases the level of Antidiuretic hormone in the blood Levamisole Approved Investigational Vet Approved Withdrawn Antidiuretic hormone increased Levamisole increases the level of Antidiuretic hormone in the blood Pentostatin Approved Investigational Antidiuretic hormone increased Pentostatin increases the level of Antidiuretic hormone in the blood Oxcarbazepine Approved Antidiuretic hormone increased Oxcarbazepine increases the level of Antidiuretic hormone in the blood Thioridazine Approved Withdrawn Antidiuretic hormone increased Thioridazine increases the level of Antidiuretic hormone in the blood Trifluoperazine Approved Investigational Antidiuretic hormone increased Trifluoperazine increases the level of Antidiuretic hormone in the blood Cisplatin Approved Antidiuretic hormone increased Cisplatin increases the level of Antidiuretic hormone in the blood Carboplatin Approved Antidiuretic hormone increased Carboplatin increases the level of Antidiuretic hormone in the blood Valproic acid Approved Investigational Antidiuretic hormone increased Valproic acid increases the level of Antidiuretic hormone in the blood Protriptyline Approved Antidiuretic hormone increased Protriptyline increases the level of Antidiuretic hormone in the blood Desipramine Approved Investigational Antidiuretic hormone increased Desipramine increases the level of Antidiuretic hormone in the blood Vincristine Approved Investigational Sodium decreased Vincristine decreases the level of Sodium in the blood Vinblastine Approved Sodium decreased Vinblastine decreases the level of Sodium in the blood Haloperidol Approved Sodium decreased Haloperidol decreases the level of Sodium in the blood Carbamazepine Approved Investigational Sodium decreased Carbamazepine decreases the level of Sodium in the blood Amiloride Approved Sodium decreased Amiloride decreases the level of Sodium in the blood Chlorpropamide Approved Investigational Sodium decreased Chlorpropamide decreases the level of Sodium in the blood Oxcarbazepine Approved Sodium decreased Oxcarbazepine decreases the level of Sodium in the blood Oxcarbazepine Approved Sodium decreased Oxcarbazepine decreases the level of Sodium in the blood Carbamazepine Approved Investigational Antidiuretic hormone increased Carbamazepine increases the level of Antidiuretic hormone in the blood