[Effects of ziprasidone and olanzapine on glucose and lipid metabolism in first-episode schizophrenia].

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Shao P, Ou J, Wu R, Fang M, Chen H, Xu Y, Zhao J

[Effects of ziprasidone and olanzapine on glucose and lipid metabolism in first-episode schizophrenia].

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2013 Apr;38(4):365-9. doi: 10.3969/j.issn.1672-7347.2013.04.005.

PubMed ID

23645236 [ View in PubMed

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Abstract

OBJECTIVE: To investigate the effect of ziprasidone and olanzapine on glucose and lipid metabolism in first-episode schizophrenia. METHODS: A total of 260 schizophrenics were assigned randomly to receive ziprasidone or olanzapine for 6 weeks. The weight was measured at baseline, week 2, 4 and 6. Fasting blood glucose (FBS), fasting insulin, high-density lipoprotein (HDL), total-cholesterol (TC) and triglycerides (TG) were measured at baseline and the end of 6-week treatment. Low-density lipoprotein (LDL) was measured in some patients at baseline and the end of 6-week treatment. Body mass index (BMI) and insulin resistance index (IRI) were counted. RESULTS: A total of 245 patients completed the trial, including 121 ziprasidone patients and 124 olanzapine patients. The average dose was 137.5 mg/d for ziprasidone and 19.5 mg/d for olanzapine. Patients treated with olanzapine had higher weight gain than those treated with ziprasidone [(4.55+/-3.37) kg vs (-0.83+/-2.05) kg, P<0.001]. After the treatment, FBS, fasting insulin, HDL, TC, TG, LDL and IRI levels were significantly increased in the olanzapine group (all P values<0.001 ). However, in the ziprasidone group, FBS decreased significantly and HDL and TG levels increased significantly after the 6-week treatment (all P values<0.05). The mean changes of FBS, fasting insulin, TC, TG, LDL and IRI were significantly different in the two groups (all P values<0.001). CONCLUSION: Ziprasidone has less glucose and lipid metabolic effect for first-episode schizophrenia patients in short-term treatment. However, olanzapine induces weight gain and dysfunction of glucose and lipid metabolism significantly, which is associated with increased risk of complications. When the doctors choose antipsychotics in the clinic, they should consider the side effects of the medication.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Ziprasidone	Approved	Glucose	decreased	Ziprasidone decreases the level of Glucose in the blood
Ziprasidone	Approved	Triglycerides	increased	Ziprasidone increases the level of Triglycerides in the blood
Olanzapine	Approved Investigational	Triglycerides	increased	Olanzapine increases the level of Triglycerides in the blood
Olanzapine	Approved Investigational	Total cholesterol	increased	Olanzapine increases the level of Total cholesterol in the blood