Effectiveness of nicotinic acid and bezafibrate alone and in combination for reducing serum triglyceride level.

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Pradhan B, Neopane A, Karki S, Karki DB

Effectiveness of nicotinic acid and bezafibrate alone and in combination for reducing serum triglyceride level.

Kathmandu Univ Med J (KUMJ). 2005 Oct-Dec;3(4):411-4.

PubMed ID

16449845 [ View in PubMed

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Abstract

OBJECTIVE: To study the effectiveness of nicotinic acid and Bezafibrate alone and in combination for reducing triglyceride level. DESIGN: It was a randomised, prospective, longitudinal study. SETTING: Patients attending a private clinic, and medical department of Kathmandu Medical College, Sinamangal. METHODS: This study included 83 consecutive patients, 19 females and 64 males with hypertriglyceridaemia (defined as serum triglyceride >200mg/dl) attending the department of medicine, Kathmandu Medical College, Sinamangal and private clinic. MAIN OUTCOME MEASURES: Statistically significant reduction of serum triglyceride level. RESULT: 51 out of 83 patients completed the study in which Nicotinic acid alone reduced the serum trygleceride level from 320.62 +/- 104.23 to 182.55 +/- 46.21, which is a reduction of 138.07 +/- 85.69 (P. value = 001). Bezafibrate when given alone also reduced triglyceride level significantly from 345.25 +/- 181.03 to 203.30+/-93.59 which is a reduction of 141.95 +/- 121.130 (P value= .001). When a combination of both drugs was given the reduction of 472.73+/-247.53 (P value =.002) was achieved. CONCLUSIONS: Nicotinic acid is a very effective drug in reducing serum triglyceride level and its effectiveness is similar to Bezafibrate. There is no added benefit of giving a combination of nicotinic acid and Bezafibrate in reducing serum triglyceride level.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Niacin	Approved Investigational Nutraceutical	Total cholesterol	decreased	Niacin decreases the level of Total cholesterol in the blood
Niacin	Approved Investigational Nutraceutical	Triglycerides	decreased	Niacin decreases the level of Triglycerides in the blood