N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.

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Sestanj K, Bellini F, Fung S, Abraham N, Treasurywala A, Humber L, Simard-Duquesne N, Dvornik D

N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.

J Med Chem. 1984 Mar;27(3):255-6.

PubMed ID

6422042 [ View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Drugs

Tolrestat

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Alrestatin	Aldose reductase	IC 50 (nM)	2700	N/A	N/A	Details
Sorbinil	Aldose reductase	IC 50 (nM)	1500	N/A	N/A	Details
Tolrestat	Aldose reductase	IC 50 (nM)	35	N/A	N/A	Details