The Association Between Antiepileptic Drugs and Bone Disease.
Article Details
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Pack AM
The Association Between Antiepileptic Drugs and Bone Disease.
Epilepsy Curr. 2003 May;3(3):91-95.
- PubMed ID
- 15309069 [ View in PubMed]
- Abstract
A growing body of literature indicates an association between antiepileptic drugs (AEDs) and bone disease, including histologic, radiographic, and biochemical evidence. The AEDs most commonly reported to cause decreased bone mineral density and disorders of bone metabolism are inducers of the cytochrome P450 enzyme system (phenobarbital, phenytoin, carbamazepine, primidone). More recent studies also suggest that valproate, an enzyme inhibitor, causes abnormalities in bone health. Multiple mechanisms have been postulated to support the association; however, no single mechanism explains all the findings. Identifying bone disease in persons with epilepsy receiving AEDs is important, as multiple treatment options are available.
DrugBank Data that Cites this Article
- Pharmaco-metabolomics
Drug Drug Groups Metabolite Change Description Phenytoin Approved Vet Approved Phosphate decreased Phenytoin decreases the level of Phosphate in the blood Phenobarbital Approved Investigational phosphate decreased Phenobarbital decreases the level of phosphate in the blood Carbamazepine Approved Investigational phosphate decreased Carbamazepine decreases the level of phosphate in the blood Primidone Approved Vet Approved phosphate decreased Primidone decreases the level of phosphate in the blood Phenobarbital Approved Investigational Calcium decreased Phenobarbital decreases the level of Calcium in the blood Phenytoin Approved Vet Approved Calcium decreased Phenytoin decreases the level of Calcium in the blood Carbamazepine Approved Investigational Calcium decreased Carbamazepine decreases the level of Calcium in the blood Primidone Approved Vet Approved Calcium decreased Primidone decreases the level of Calcium in the blood