The Association Between Antiepileptic Drugs and Bone Disease.

Article Details

Citation

Pack AM

The Association Between Antiepileptic Drugs and Bone Disease.

Epilepsy Curr. 2003 May;3(3):91-95.

PubMed ID
15309069 [ View in PubMed
]
Abstract

A growing body of literature indicates an association between antiepileptic drugs (AEDs) and bone disease, including histologic, radiographic, and biochemical evidence. The AEDs most commonly reported to cause decreased bone mineral density and disorders of bone metabolism are inducers of the cytochrome P450 enzyme system (phenobarbital, phenytoin, carbamazepine, primidone). More recent studies also suggest that valproate, an enzyme inhibitor, causes abnormalities in bone health. Multiple mechanisms have been postulated to support the association; however, no single mechanism explains all the findings. Identifying bone disease in persons with epilepsy receiving AEDs is important, as multiple treatment options are available.

DrugBank Data that Cites this Article

Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
PhenytoinApproved Vet ApprovedPhosphate
decreased
Phenytoin decreases the level of Phosphate in the blood
PhenobarbitalApproved Investigationalphosphate
decreased
Phenobarbital decreases the level of phosphate in the blood
CarbamazepineApproved Investigationalphosphate
decreased
Carbamazepine decreases the level of phosphate in the blood
PrimidoneApproved Vet Approvedphosphate
decreased
Primidone decreases the level of phosphate in the blood
PhenobarbitalApproved InvestigationalCalcium
decreased
Phenobarbital decreases the level of Calcium in the blood
PhenytoinApproved Vet ApprovedCalcium
decreased
Phenytoin decreases the level of Calcium in the blood
CarbamazepineApproved InvestigationalCalcium
decreased
Carbamazepine decreases the level of Calcium in the blood
PrimidoneApproved Vet ApprovedCalcium
decreased
Primidone decreases the level of Calcium in the blood