Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder.
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Pillai BP, Unnikrishnan AG, Pavithran PV
Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder.
Indian J Endocrinol Metab. 2011 Sep;15 Suppl 3:S208-15. doi: 10.4103/2230-8210.84870.
- PubMed ID
- 22029026 [ View in PubMed]
- Abstract
Hyponatremia occurs in about 30% of hospitalized patients and syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of hyponatremia. SIADH should be differentiated from other causes of hyponatremia like diuretic therapy, hypothyroidism and hypocortisolism. Where possible, all attempts should be made to identify and rectify the cause of SIADH. The main problem in SIADH is fluid excess, and hyponatremia is dilutional in nature. Fluid restriction is the main stay in the treatment of SIADH; however, cerebral salt wasting should be excluded in the clinical setting of brain surgeries, subarachnoid hemorrhage, etc. Fluid restriction in cerebral salt wasting can be hazardous. Sodium correction in chronic hyponatremia (onset >48 hours) should be done slowly to avoid deleterious effects in brain.
DrugBank Data that Cites this Article
- Pharmaco-metabolomics
Drug Drug Groups Metabolite Change Description Morphine Approved Investigational Antidiuretic hormone increased Morphine increases the level of Antidiuretic hormone in the blood Oxcarbazepine Approved Antidiuretic hormone increased Oxcarbazepine increases the level of Antidiuretic hormone in the blood Chlorpropamide Approved Investigational Antidiuretic hormone increased Chlorpropamide increases the level of Antidiuretic hormone in the blood Vincristine Approved Investigational Antidiuretic hormone increased Vincristine increases the level of Antidiuretic hormone in the blood Vinorelbine Approved Investigational Antidiuretic hormone increased Vinorelbine increases the level of Antidiuretic hormone in the blood Amiodarone Approved Investigational Antidiuretic hormone increased Amiodarone increases the level of Antidiuretic hormone in the blood Ciprofloxacin Approved Investigational Antidiuretic hormone increased Ciprofloxacin increases the level of Antidiuretic hormone in the blood Vinblastine Approved Antidiuretic hormone increased Vinblastine increases the level of Antidiuretic hormone in the blood Cisplatin Approved Antidiuretic hormone increased Cisplatin increases the level of Antidiuretic hormone in the blood Thiothixene Approved Antidiuretic hormone increased Thiothixene increases the level of Antidiuretic hormone in the blood Haloperidol Approved Antidiuretic hormone increased Haloperidol increases the level of Antidiuretic hormone in the blood Amitriptyline Approved Antidiuretic hormone increased Amitriptyline increases the level of Antidiuretic hormone in the blood Melphalan Approved Antidiuretic hormone increased Melphalan increases the level of Antidiuretic hormone in the blood Imatinib Approved Antidiuretic hormone increased Imatinib increases the level of Antidiuretic hormone in the blood Methotrexate Approved Antidiuretic hormone increased Methotrexate increases the level of Antidiuretic hormone in the blood Ifosfamide Approved Antidiuretic hormone increased Ifosfamide increases the level of Antidiuretic hormone in the blood Bromocriptine Approved Investigational Withdrawn Antidiuretic hormone increased Bromocriptine increases the level of Antidiuretic hormone in the blood Oxcarbazepine Approved Sodium decreased Oxcarbazepine decreases the level of Sodium in the blood Chlorpropamide Approved Investigational Sodium decreased Chlorpropamide decreases the level of Sodium in the blood Vincristine Approved Investigational Sodium decreased Vincristine decreases the level of Sodium in the blood Vinorelbine Approved Investigational Sodium decreased Vinorelbine decreases the level of Sodium in the blood Amiodarone Approved Investigational Sodium decreased Amiodarone decreases the level of Sodium in the blood Ciprofloxacin Approved Investigational Sodium decreased Ciprofloxacin decreases the level of Sodium in the blood Vinblastine Approved Sodium decreased Vinblastine decreases the level of Sodium in the blood Cisplatin Approved Sodium decreased Cisplatin decreases the level of Sodium in the blood Thiothixene Approved Sodium decreased Thiothixene decreases the level of Sodium in the blood Haloperidol Approved Sodium decreased Haloperidol decreases the level of Sodium in the blood Amitriptyline Approved Sodium decreased Amitriptyline decreases the level of Sodium in the blood Melphalan Approved Sodium decreased Melphalan decreases the level of Sodium in the blood Imatinib Approved Sodium decreased Imatinib decreases the level of Sodium in the blood Methotrexate Approved Sodium decreased Methotrexate decreases the level of Sodium in the blood Ifosfamide Approved Sodium decreased Ifosfamide decreases the level of Sodium in the blood Bromocriptine Approved Investigational Withdrawn Sodium decreased Bromocriptine decreases the level of Sodium in the blood