Oral retinoids and plasma lipids.

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Lilley JS, Linton MF, Fazio S

Oral retinoids and plasma lipids.

Dermatol Ther. 2013 Sep-Oct;26(5):404-10. doi: 10.1111/dth.12085.

PubMed ID

24099071 [ View in PubMed

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Abstract

Retinoids and rexinoids are prescribed for conditions ranging from acne vulgaris to hyperkeratosis to cutaneous T cell lymphoma. Dyslipidemia is a frequent consequence of the use of these drugs, with more than one-third of patients manifesting aberrations in triglyceride (TG) levels. The efficacy of retinoic acid derivatives is linked to their influence on lipid metabolism in the skin, which can impair systemic lipid trafficking and metabolism in some patients. Thus, baseline screening for preexisting dyslipidemia and regular follow-up lipid panels are mandated, especially when powerful agents such as bexarotene are used. Dietary modification, increased physical activity, and weight management are the cornerstones of initial management for mild hypertriglyceridemia, which is a contributor to cardiovascular risk. More severe impairments (fasting TG > 500 mg/dL) warrant pharmacologic interventions early on to reduce the risk of pancreatitis. Retinoic acid derivative action, lipid metabolism, and treatment of incident dyslipidemias are reviewed to empower prescribers in management of adverse lipid effects.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Gemfibrozil	Approved	Triglycerides	decreased	Gemfibrozil decreases the level of Triglycerides in the blood
Niacin	Approved Investigational Nutraceutical	Triglycerides	decreased	Niacin decreases the level of Triglycerides in the blood
Fenofibrate	Approved	Triglycerides	decreased	Fenofibrate decreases the level of Triglycerides in the blood