Influence of drugs on vitamin D and calcium metabolism.

Article Details

Citation

Grober U, Kisters K

Influence of drugs on vitamin D and calcium metabolism.

Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.

PubMed ID
22928072 [ View in PubMed
]
Abstract

In the past, interactions between drugs and vitamin D have received only little or no attention in the health care practices. However, since more and more drugs are used for the treatment of patients, this topic is increasingly relevant. Several drugs can interfere with the vitamin D and bone metabolism. Drugs that activate the pregnane X receptor can disrupt vitamin D metabolism and vitamin D function. Beside this, the medication oriented supplementation of vitamin D can ameliorate the pharmacologic action of some drugs, such as bisphosphonates, cytostatics and statins.

DrugBank Data that Cites this Article

Drug Interactions
DrugsInteraction
Alfacalcidol
Phenytoin
The serum concentration of Alfacalcidol can be decreased when it is combined with Phenytoin.
Alfacalcidol
Fosphenytoin
The serum concentration of Alfacalcidol can be decreased when it is combined with Fosphenytoin.
Calcifediol
Phenytoin
The serum concentration of Calcifediol can be decreased when it is combined with Phenytoin.
Calcifediol
Fosphenytoin
The serum concentration of Calcifediol can be decreased when it is combined with Fosphenytoin.
Calcipotriol
Phenytoin
The serum concentration of Calcipotriol can be decreased when it is combined with Phenytoin.
Calcipotriol
Fosphenytoin
The serum concentration of Calcipotriol can be decreased when it is combined with Fosphenytoin.
Calcitriol
Fosphenytoin
The serum concentration of Calcitriol can be decreased when it is combined with Fosphenytoin.
Calcitriol
Phenytoin
The serum concentration of Calcitriol can be decreased when it is combined with Phenytoin.
Cholecalciferol
Fosphenytoin
The serum concentration of Cholecalciferol can be decreased when it is combined with Fosphenytoin.
Dexpanthenol
Phenytoin
The serum concentration of Dexpanthenol can be decreased when it is combined with Phenytoin.
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Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
PhenytoinApproved Vet Approved25-hydroxyvitamin D
decreased
Phenytoin decreases the level of 25-hydroxyvitamin D in the blood
CarbamazepineApproved Investigational25-hydroxyvitamin D
decreased
Carbamazepine decreases the level of 25-hydroxyvitamin D in the blood
TamoxifenApproved25-hydroxyvitamin D
decreased
Tamoxifen decreases the level of 25-hydroxyvitamin D in the blood
ClotrimazoleApproved Vet Approved25-hydroxyvitamin D
decreased
Clotrimazole decreases the level of 25-hydroxyvitamin D in the blood
RifampicinApproved25-hydroxyvitamin D
decreased
Rifampicin decreases the level of 25-hydroxyvitamin D in the blood
DexamethasoneApproved Investigational Vet Approved25-hydroxyvitamin D
decreased
Dexamethasone decreases the level of 25-hydroxyvitamin D in the blood
NifedipineApproved25-hydroxyvitamin D
decreased
Nifedipine decreases the level of 25-hydroxyvitamin D in the blood
SpironolactoneApproved25-hydroxyvitamin D
decreased
Spironolactone decreases the level of 25-hydroxyvitamin D in the blood
SaquinavirApproved Investigational25-hydroxyvitamin D
decreased
Saquinavir decreases the level of 25-hydroxyvitamin D in the blood
Cyproterone acetateApproved Investigational25-hydroxyvitamin D
decreased
Cyproterone acetate decreases the level of 25-hydroxyvitamin D in the blood
HyperforinNutraceutical25-hydroxyvitamin D
decreased
Hyperforin decreases the level of 25-hydroxyvitamin D in the blood
PrimidoneApproved Vet Approved25-hydroxyvitamin D
decreased
Primidone decreases the level of 25-hydroxyvitamin D in the blood
PhenytoinApproved Vet Approved1,25-dihydroxyvitamin D3
decreased
Phenytoin decreases the level of 1,25-dihydroxyvitamin D3 in the blood
CarbamazepineApproved Investigational1,25-dihydroxyvitamin D3
decreased
Carbamazepine decreases the level of 1,25-dihydroxyvitamin D3 in the blood
TamoxifenApproved1,25-dihydroxyvitamin D3
decreased
Tamoxifen decreases the level of 1,25-dihydroxyvitamin D3 in the blood
ClotrimazoleApproved Vet Approved1,25-dihydroxyvitamin D3
decreased
Clotrimazole decreases the level of 1,25-dihydroxyvitamin D3 in the blood
RifampicinApproved1,25-dihydroxyvitamin D3
decreased
Rifampicin decreases the level of 1,25-dihydroxyvitamin D3 in the blood
DexamethasoneApproved Investigational Vet Approved1,25-dihydroxyvitamin D3
decreased
Dexamethasone decreases the level of 1,25-dihydroxyvitamin D3 in the blood
NifedipineApproved1,25-dihydroxyvitamin D3
decreased
Nifedipine decreases the level of 1,25-dihydroxyvitamin D3 in the blood
SpironolactoneApproved1,25-dihydroxyvitamin D3
decreased
Spironolactone decreases the level of 1,25-dihydroxyvitamin D3 in the blood
SaquinavirApproved Investigational1,25-dihydroxyvitamin D3
decreased
Saquinavir decreases the level of 1,25-dihydroxyvitamin D3 in the blood
Cyproterone acetateApproved Investigational1,25-dihydroxyvitamin D3
decreased
Cyproterone acetate decreases the level of 1,25-dihydroxyvitamin D3 in the blood
HyperforinNutraceutical1,25-dihydroxyvitamin D3
decreased
Hyperforin decreases the level of 1,25-dihydroxyvitamin D3 in the blood
PrimidoneApproved Vet Approved1,25-dihydroxyvitamin D3
decreased
Primidone decreases the level of 1,25-dihydroxyvitamin D3 in the blood
PhenobarbitalApproved Investigational25-hydroxyvitamin D
decreased
Phenobarbital decreases the level of 25-hydroxyvitamin D in the blood
Valproic acidApproved Investigational25-hydroxyvitamin D
decreased
Valproic acid decreases the level of 25-hydroxyvitamin D in the blood