Influence of drugs on vitamin D and calcium metabolism.
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Grober U, Kisters K
Influence of drugs on vitamin D and calcium metabolism.
Dermatoendocrinol. 2012 Apr 1;4(2):158-66. doi: 10.4161/derm.20731.
- PubMed ID
- 22928072 [ View in PubMed]
- Abstract
In the past, interactions between drugs and vitamin D have received only little or no attention in the health care practices. However, since more and more drugs are used for the treatment of patients, this topic is increasingly relevant. Several drugs can interfere with the vitamin D and bone metabolism. Drugs that activate the pregnane X receptor can disrupt vitamin D metabolism and vitamin D function. Beside this, the medication oriented supplementation of vitamin D can ameliorate the pharmacologic action of some drugs, such as bisphosphonates, cytostatics and statins.
DrugBank Data that Cites this Article
- Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareAlfacalcidolPhenytoin The serum concentration of Alfacalcidol can be decreased when it is combined with Phenytoin. AlfacalcidolFosphenytoin The serum concentration of Alfacalcidol can be decreased when it is combined with Fosphenytoin. CalcifediolPhenytoin The serum concentration of Calcifediol can be decreased when it is combined with Phenytoin. CalcifediolFosphenytoin The serum concentration of Calcifediol can be decreased when it is combined with Fosphenytoin. CalcipotriolPhenytoin The serum concentration of Calcipotriol can be decreased when it is combined with Phenytoin. - Pharmaco-metabolomics
Drug Drug Groups Metabolite Change Description Phenytoin Approved Vet Approved 25-hydroxyvitamin D decreased Phenytoin decreases the level of 25-hydroxyvitamin D in the blood Carbamazepine Approved Investigational 25-hydroxyvitamin D decreased Carbamazepine decreases the level of 25-hydroxyvitamin D in the blood Tamoxifen Approved 25-hydroxyvitamin D decreased Tamoxifen decreases the level of 25-hydroxyvitamin D in the blood Clotrimazole Approved Vet Approved 25-hydroxyvitamin D decreased Clotrimazole decreases the level of 25-hydroxyvitamin D in the blood Rifampicin Approved 25-hydroxyvitamin D decreased Rifampicin decreases the level of 25-hydroxyvitamin D in the blood Dexamethasone Approved Investigational Vet Approved 25-hydroxyvitamin D decreased Dexamethasone decreases the level of 25-hydroxyvitamin D in the blood Nifedipine Approved 25-hydroxyvitamin D decreased Nifedipine decreases the level of 25-hydroxyvitamin D in the blood Spironolactone Approved 25-hydroxyvitamin D decreased Spironolactone decreases the level of 25-hydroxyvitamin D in the blood Saquinavir Approved Investigational 25-hydroxyvitamin D decreased Saquinavir decreases the level of 25-hydroxyvitamin D in the blood Cyproterone acetate Approved Investigational 25-hydroxyvitamin D decreased Cyproterone acetate decreases the level of 25-hydroxyvitamin D in the blood Hyperforin Nutraceutical 25-hydroxyvitamin D decreased Hyperforin decreases the level of 25-hydroxyvitamin D in the blood Primidone Approved Vet Approved 25-hydroxyvitamin D decreased Primidone decreases the level of 25-hydroxyvitamin D in the blood Phenytoin Approved Vet Approved 1,25-dihydroxyvitamin D3 decreased Phenytoin decreases the level of 1,25-dihydroxyvitamin D3 in the blood Carbamazepine Approved Investigational 1,25-dihydroxyvitamin D3 decreased Carbamazepine decreases the level of 1,25-dihydroxyvitamin D3 in the blood Tamoxifen Approved 1,25-dihydroxyvitamin D3 decreased Tamoxifen decreases the level of 1,25-dihydroxyvitamin D3 in the blood Clotrimazole Approved Vet Approved 1,25-dihydroxyvitamin D3 decreased Clotrimazole decreases the level of 1,25-dihydroxyvitamin D3 in the blood Rifampicin Approved 1,25-dihydroxyvitamin D3 decreased Rifampicin decreases the level of 1,25-dihydroxyvitamin D3 in the blood Dexamethasone Approved Investigational Vet Approved 1,25-dihydroxyvitamin D3 decreased Dexamethasone decreases the level of 1,25-dihydroxyvitamin D3 in the blood Nifedipine Approved 1,25-dihydroxyvitamin D3 decreased Nifedipine decreases the level of 1,25-dihydroxyvitamin D3 in the blood Spironolactone Approved 1,25-dihydroxyvitamin D3 decreased Spironolactone decreases the level of 1,25-dihydroxyvitamin D3 in the blood Saquinavir Approved Investigational 1,25-dihydroxyvitamin D3 decreased Saquinavir decreases the level of 1,25-dihydroxyvitamin D3 in the blood Cyproterone acetate Approved Investigational 1,25-dihydroxyvitamin D3 decreased Cyproterone acetate decreases the level of 1,25-dihydroxyvitamin D3 in the blood Hyperforin Nutraceutical 1,25-dihydroxyvitamin D3 decreased Hyperforin decreases the level of 1,25-dihydroxyvitamin D3 in the blood Primidone Approved Vet Approved 1,25-dihydroxyvitamin D3 decreased Primidone decreases the level of 1,25-dihydroxyvitamin D3 in the blood Phenobarbital Approved Investigational 25-hydroxyvitamin D decreased Phenobarbital decreases the level of 25-hydroxyvitamin D in the blood Valproic acid Approved Investigational 25-hydroxyvitamin D decreased Valproic acid decreases the level of 25-hydroxyvitamin D in the blood