Melatonin and corticosteroid response to metyrapone in patients with pituitary disease.
Article Details
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Brismar K, Werner S, Wetterberg L
Melatonin and corticosteroid response to metyrapone in patients with pituitary disease.
Prog Clin Biol Res. 1982;92:283-92.
- PubMed ID
- 6287497 [ View in PubMed]
- Abstract
Melatonin secretion is dependent both on the environmental lighting and noradrenergic control and seems to be related to the ACTH-cortisol secretion. The aim of the present study was to further elucidate the relationship between ACTH-cortisol and melatonin. For this purpose we chose the Metyrapone test. The melatonin secretion was studied in 10 patients, and increased significantly in 8/10 during and in one after the Metyrapone administration. These results further support a relationship between melatonin and ACTH-cortisol secretion, possibly through a suprapituitary interaction.
DrugBank Data that Cites this Article
- Pharmaco-metabolomics
Drug Drug Groups Metabolite Change Description Metyrapone Approved Investigational melatonin increased Metyrapone increases the level of melatonin in the blood