Melatonin and corticosteroid response to metyrapone in patients with pituitary disease.

Article Details

Citation

Brismar K, Werner S, Wetterberg L

Melatonin and corticosteroid response to metyrapone in patients with pituitary disease.

Prog Clin Biol Res. 1982;92:283-92.

PubMed ID
6287497 [ View in PubMed
]
Abstract

Melatonin secretion is dependent both on the environmental lighting and noradrenergic control and seems to be related to the ACTH-cortisol secretion. The aim of the present study was to further elucidate the relationship between ACTH-cortisol and melatonin. For this purpose we chose the Metyrapone test. The melatonin secretion was studied in 10 patients, and increased significantly in 8/10 during and in one after the Metyrapone administration. These results further support a relationship between melatonin and ACTH-cortisol secretion, possibly through a suprapituitary interaction.

DrugBank Data that Cites this Article

Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
MetyraponeApproved Investigationalmelatonin
increased
Metyrapone increases the level of melatonin in the blood