Effect of ibuprofen on bilirubin-albumin binding.

Article Details

Citation

Ahlfors CE

Effect of ibuprofen on bilirubin-albumin binding.

J Pediatr. 2004 Mar;144(3):386-8.

PubMed ID
15001951 [ View in PubMed
]
Abstract

Ibuprofen is used for closing the ductus arteriosus in premature newborn infants. Ibuprofen interferes with bilirubin-albumin binding and increases the unbound bilirubin in pooled newborn plasma to levels similar to those produced by sulfisoxazole, a drug that causes kernicterus in premature newborn infants.

DrugBank Data that Cites this Article

Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
SulfisoxazoleApproved Vet Approvedtotal bilirubin
decreased
Sulfisoxazole decreases the level of total bilirubin in the blood