Effect of opium addiction on new and traditional cardiovascular risk factors: do duration of addiction and route of administration matter?

Article Details

Citation

Asgary S, Sarrafzadegan N, Naderi GA, Rozbehani R

Effect of opium addiction on new and traditional cardiovascular risk factors: do duration of addiction and route of administration matter?

Lipids Health Dis. 2008 Nov 3;7:42. doi: 10.1186/1476-511X-7-42.

PubMed ID
18980684 [ View in PubMed
]
Abstract

BACKGROUND: There is a belief among some society that opium has a number of beneficial effects on cardiovascular disease. The aim of the present investigation as a cross-sectional study was to assess this hypothesis. Several biochemical factors (Fasting blood sugar, Cholesterol, Triglyceride, LDL-Cholesterol, HDL-Cholesterol, HbA1C, CRP, Fibrinogen, Factor VII, SGOT, SGPT, Lpa, apo A and apo B were evaluated in opium-addicted men (case) against non opium-addicted men(control). Three hundred and sixty opium-addicted men were divided into three groups according to the route of administration (Orally, Vafour and Sikh-Sang) and each group was divided into four subgroups according to the duration of addiction (5 months, 1 year, 2 years and 5 years). Blood morphine concentration was measured by ELISA method. RESULTS: The results show that morphine concentration was significantly higher in orally administration. In all routes, there was a direct correlation between blood morphine concentration and period of addiction. Regardless to the period and route of administration, the level of HbA1C, CRP, factor VII, Fibrinogen, apo B, Lpa, SGOT, and SGPT were significantly higher in the case subjects as compared with controls and HDL-Cholesterol and apo a were significantly lower in the case subjects. CONCLUSION: This study demonstrated the deleterious effects of opium on some traditional and new cardiovascular disease risk factors. These deleterious effects are related to the period of addiction and their levels are significantly increased after 2 years of addiction. Route of administration impresses cardiovascular risk factors and "Sikh-Sang" showed the worst effect.

DrugBank Data that Cites this Article

Pharmaco-proteomics
DrugDrug GroupsGeneGene IDChangeInteractionChromosome
MorphineApproved InvestigationalAPOB338
increased
Morphine results in increased expression of APOB protein2p24.1
MorphineApproved InvestigationalCRP1401
increased
Morphine results in increased expression of CRP protein1q23.2
MorphineApproved InvestigationalF72155
increased
Morphine results in increased expression of F7 protein13q34