Multiple metals predict prolactin and thyrotropin (TSH) levels in men.
Article Details
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Meeker JD, Rossano MG, Protas B, Diamond MP, Puscheck E, Daly D, Paneth N, Wirth JJ
Multiple metals predict prolactin and thyrotropin (TSH) levels in men.
Environ Res. 2009 Oct;109(7):869-73. doi: 10.1016/j.envres.2009.06.004.
- PubMed ID
- 19595304 [ View in PubMed]
- Abstract
Exposure to a number of metals can affect neuroendocrine and thyroid signaling, which can result in adverse effects on development, behavior, metabolism, reproduction, and other functions. The present study assessed the relationship between metal concentrations in blood and serum prolactin (PRL) and thyrotropin (TSH) levels, markers of dopaminergic, and thyroid function, respectively, among men participating in a study of environmental influences on male reproductive health. Blood samples from 219 men were analyzed for concentrations of 11 metals and serum levels of PRL and TSH. In multiple linear regression models adjusted for age, BMI and smoking, PRL was inversely associated with arsenic, cadmium, copper, lead, manganese, molybdenum, and zinc, but positively associated with chromium. Several of these associations (Cd, Pb, Mo) are consistent with limited studies in humans or animals, and a number of the relationships (Cr, Cu, Pb, Mo) remained when additionally considering multiple metals in the model. Lead and copper were associated with non-monotonic decrease in TSH, while arsenic was associated with a dose-dependent increase in TSH. For arsenic these findings were consistent with recent experimental studies where arsenic inhibited enzymes involved in thyroid hormone synthesis and signaling. More research is needed for a better understanding of the role of metals in neuroendocrine and thyroid function and related health implications.
DrugBank Data that Cites this Article
- Pharmaco-proteomics
Drug Drug Groups Gene Gene ID Change Interaction Chromosome Copper Approved Investigational PRL 5617 decreased Copper results in decreased expression of PRL protein 6p22.3 Manganese Approved Nutraceutical PRL 5617 decreased Manganese results in decreased expression of PRL protein 6p22.3 Molybdenum Approved PRL 5617 decreased Molybdenum results in decreased expression of PRL protein 6p22.3 Zinc Approved Investigational PRL 5617 decreased Zinc results in decreased expression of PRL protein 6p22.3 Chromium Approved PRL 5617 increased Chromium results in increased expression of PRL protein 6p22.3