Intravenous calcitriol therapy increases serum concentrations of fibroblast growth factor-23 in dialysis patients with secondary hyperparathyroidism.

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Nishi H, Nii-Kono T, Nakanishi S, Yamazaki Y, Yamashita T, Fukumoto S, Ikeda K, Fujimori A, Fukagawa M

Intravenous calcitriol therapy increases serum concentrations of fibroblast growth factor-23 in dialysis patients with secondary hyperparathyroidism.

Nephron Clin Pract. 2005;101(2):c94-9. Epub 2005 Jun 14.

PubMed ID

15956805 [ View in PubMed

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Abstract

BACKGROUND/AIMS: Fibroblast growth factor-23 (FGF-23) is a recently discovered phosphaturic factor. Although increased levels of serum FGF-23 have been reported in dialysis patients, the role of high FGF-23 levels remains unclear. Since FGF-23 is associated also with vitamin D metabolism, we examined the changes of serum FGF-23 levels in chronic dialysis patients treated with intravenous calcitriol therapy. METHODS: Thirty patients with severe secondary hyperparathyroidism were treated with intravenous calcitriol (0.5-1.0 microg) two or three times per week for 6 months. The changes of serum levels of calcium, phosphate, intact PTH, and FGF-23 were evaluated. RESULTS: Baseline serum FGF-23 levels were markedly high. By intravenous calcitriol therapy, intact PTH levels decreased effectively in the first month (p < 0.001). In contrast, FGF-23 levels increased gradually during the study period (p = 0.027). The Delta serum FGF-23 level was significantly correlated with the total doses of calcitriol injected intravenously in 6 months in patients with refractory secondary hyperparathyroidism (R2 = 0.147; p = 0.036). CONCLUSIONS: Intravenous calcitriol decreased serum intact PTH level and increased serum FGF-23 levels significantly. Extremely high levels of serum FGF-23 in these patients may be attributed, at least in part, to the cumulative dose of vitamin D.

DrugBank Data that Cites this Article

Pharmaco-proteomics

Drug	Drug Groups	Gene	Gene ID	Change	Interaction	Chromosome
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	PTH	5741	decreased	Calcitriol results in decreased expression of PTH protein	11p15.3
Calcitriol	Approved Nutraceutical	FGF23	8074	increased	Calcitriol results in increased expression of FGF23 protein	12p13.32
Calcitriol	Approved Nutraceutical	FGF23	8074	increased	Calcitriol results in increased expression of FGF23 protein	12p13.32
Calcitriol	Approved Nutraceutical	FGF23	8074	increased	Calcitriol results in increased expression of FGF23 protein	12p13.32