Treatment of primary hypercholesterolemia: fluvastatin versus bezafibrate.

Article Details

Citation

Greten H, Beil FU, Schneider J, Weisweiler P, Armstrong VW, Keller C, Klor HU, von Hodenberg E, Weidinger G, Eskotter H, et al.

Treatment of primary hypercholesterolemia: fluvastatin versus bezafibrate.

Am J Med. 1994 Jun 6;96(6A):55S-63S.

PubMed ID
8017468 [ View in PubMed
]
Abstract

The effects of fluvastatin and bezafibrate on lipids, lipoproteins, and apoproteins (apo) were investigated in a multicenter randomized, double-blind, parallel-group study. After 8 weeks of strictly controlled (computer-based assessment) dietary stabilization, patients with primary hypercholesterolemia (low-density lipoprotein cholesterol [LDL-C] > or = 160 mg/dL; triglycerides < or = 300 mg/dL) were enrolled into a 6-week placebo phase. Altogether, 131 patients were randomized to receive either fluvastatin at 40 mg once daily (n = 64; mean age 53 years) or bezafibrate at 400 mg once daily (n = 67; mean age 52 years) for 12 weeks. Compliance with the diet was monitored (3-day food records) after 6 and 12 weeks. Fluvastatin led to significant reductions in LDL-C (-23%), total cholesterol (-17%), LDL-C/high-density lipoprotein cholesterol (HDL-C) (-24%) and apo B (-19%). Fluvastatin significantly increased LpA-I (+8%) and apo E (+20%). Bezafibrate produced significant reductions in LDL-C (-17%), total cholesterol (-13%), LDL-C/HDL-C (-24%), triglycerides (-28%), apo B (-15%), and LpA-I (-10%) and significantly increased HDL-C (+12%), apo A-I (+9%), apo A-II (+30%), apo E (+14%), and Lp(a) (+3%). No clinically notable increases in levels of liver enzymes or creatine phosphokinase were observed with either treatment. Both treatments were well tolerated. There was a low incidence of adverse events that tended to be mild and included headache, muscular pain, angina, and dyspepsia. The frequency of adverse events was similar in both treatment groups, and no significant differences in dietary behavior were observed. In conclusion, fluvastatin is a well tolerated 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor for the treatment of primary hypercholesterolemia. Effects of fluvastatin on LpA-I occur irrespective of changes in HDL-C.

DrugBank Data that Cites this Article

Pharmaco-proteomics
DrugDrug GroupsGeneGene IDChangeInteractionChromosome
BezafibrateApproved InvestigationalAPOB338
decreased
Bezafibrate results in decreased expression of APOB protein2p24.1
BezafibrateApproved InvestigationalAPOB338
decreased
Bezafibrate results in decreased expression of APOB protein2p24.1
BezafibrateApproved InvestigationalAPOB338
decreased
Bezafibrate results in decreased expression of APOB protein2p24.1
BezafibrateApproved InvestigationalAPOB338
decreased
Bezafibrate results in decreased expression of APOB protein2p24.1
BezafibrateApproved InvestigationalAPOB338
decreased
Bezafibrate results in decreased expression of APOB protein2p24.1
BezafibrateApproved InvestigationalAPOA1335
increased
Bezafibrate results in increased expression of APOA1 protein11q23.3
BezafibrateApproved InvestigationalAPOA1335
increased
Bezafibrate results in increased expression of APOA1 protein11q23.3
BezafibrateApproved InvestigationalAPOA1335
increased
Bezafibrate results in increased expression of APOA1 protein11q23.3
BezafibrateApproved InvestigationalAPOA2336
increased
Bezafibrate results in increased expression of APOA2 protein1q23.3