Synthesis of the bicyclic core of tagetitoxin.

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Citation

Plet JR, Porter MJ

Synthesis of the bicyclic core of tagetitoxin.

Chem Commun (Camb). 2006 Mar 21;(11):1197-9. Epub 2006 Feb 14.

PubMed ID
16518489 [ View in PubMed
]
Abstract

A synthesis of the 9-oxa-3-thiabicyclo[3.3.1]nonane ring system, which constitutes the core of the RNA polymerase inhibitor tagetitoxin, has been achieved through cyclisation of a thiol onto an electrophilic ketone.

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