Pituitary apoplexy following chlorpromazine stimulation.

Article Details

Citation

Silverman VE, Boyd AE 3rd, McCrary JA 3rd, Kohler PO

Pituitary apoplexy following chlorpromazine stimulation.

Arch Intern Med. 1978 Nov;138(11):1738-9.

PubMed ID
718334 [ View in PubMed
]
Abstract

Chlorpromazine is frequently administered to patients with hyperprolactinemia to stimulate an increase in the serum levels of prolactin. A patient with a prolactin secreting adenoma is described in whom pituitary apoplexy developed in association with a hypotensive episode following the administration of 25 mg of chlorpromazine. Prolactin levels fell from more than 2,000 ng/ml to 340 ng/ml following infarction of the pituitary tumor. Pituitary apoplexy should be considered as a rare complication of chlorpromazine stimulation in a patient with a pituitary tumor.

DrugBank Data that Cites this Article

Pharmaco-proteomics
DrugDrug GroupsGeneGene IDChangeInteractionChromosome
ChlorpromazineApproved Investigational Vet ApprovedPRL5617
increased
Chlorpromazine results in increased expression of PRL protein6p22.3
ChlorpromazineApproved Investigational Vet ApprovedPRL5617
increased
Chlorpromazine results in increased expression of PRL protein6p22.3