Pituitary apoplexy following chlorpromazine stimulation.
Article Details
- CitationCopy to clipboard
Silverman VE, Boyd AE 3rd, McCrary JA 3rd, Kohler PO
Pituitary apoplexy following chlorpromazine stimulation.
Arch Intern Med. 1978 Nov;138(11):1738-9.
- PubMed ID
- 718334 [ View in PubMed]
- Abstract
Chlorpromazine is frequently administered to patients with hyperprolactinemia to stimulate an increase in the serum levels of prolactin. A patient with a prolactin secreting adenoma is described in whom pituitary apoplexy developed in association with a hypotensive episode following the administration of 25 mg of chlorpromazine. Prolactin levels fell from more than 2,000 ng/ml to 340 ng/ml following infarction of the pituitary tumor. Pituitary apoplexy should be considered as a rare complication of chlorpromazine stimulation in a patient with a pituitary tumor.
DrugBank Data that Cites this Article
- Pharmaco-proteomics
Drug Drug Groups Gene Gene ID Change Interaction Chromosome Chlorpromazine Approved Investigational Vet Approved PRL 5617 increased Chlorpromazine results in increased expression of PRL protein 6p22.3 Chlorpromazine Approved Investigational Vet Approved PRL 5617 increased Chlorpromazine results in increased expression of PRL protein 6p22.3