Augmented photoswitching modulates immune signaling.

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Zhang Y, Erdmann F, Fischer G

Augmented photoswitching modulates immune signaling.

Nat Chem Biol. 2009 Oct;5(10):724-6. doi: 10.1038/nchembio.214. Epub 2009 Sep 6.

PubMed ID

19734911 [ View in PubMed

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Abstract

Reversible and non-invasive photoswitching of the immunosuppressive effect of a drug would be a very valuable tool for precisely regulating the immune system. Using a combination of protein borrowing and two-photon photoisomerization, we designed and synthesized derivatives of cyclosporin A. Here we demonstrate photoswitching of the local conformation within small molecules, which we used to modulate inhibitory potencies for cyclophilin, influence ternary and quaternary complex formations and regulate T-cell transcriptional activation in situ.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Cyclosporine	Peptidyl-prolyl cis-trans isomerase A	IC 50 (nM)	3.7	N/A	N/A	Details
Cyclosporine	Peptidyl-prolyl cis-trans isomerase A	Kd (nM)	9	N/A	N/A	Details
Cyclosporine	Peptidyl-prolyl cis-trans isomerase A	IC 50 (nM)	100	N/A	N/A	Details