Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents.

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Scribner A, Houck D, Huang Z, Mosier S, Peel M, Scorneaux B

Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6542-6. doi: 10.1016/j.bmcl.2010.09.036. Epub 2010 Sep 21.

PubMed ID

20943390 [ View in PubMed

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Abstract

An efficient synthesis of [D-lysine](8)cyclosporin A has been developed. Several analogs of [D-lysine](8)cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC(50)<200 nM, and are each >/=50-fold less immunosuppressive than cyclosporin A.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Cyclosporine	Peptidyl-prolyl cis-trans isomerase A	IC 50 (nM)	8.33	N/A	N/A	Details