3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.

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Dogruer D, Lee M, Dukat M, Damaj MI, Martin BR, Glennon RA

3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):523-6.

PubMed ID

14698195 [ View in PubMed

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Abstract

The binding of a series pyridylbutynylamines 6 was examined at alpha4beta2 nACh receptors. Structural modifications, comparing 6 with pyridyl ethers 2, did not consistently result in parallel effects on receptor affinity, suggesting possible differences in their modes of binding. Furthermore, the binding of amine 6a seemed to be accounted for by the newer vector pharmacophore models.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Nicotine	Neuronal acetylcholine receptor subunit beta-2	Ki (nM)	2.1	N/A	N/A	Details
Rivanicline	Neuronal acetylcholine receptor subunit beta-2	Ki (nM)	25	N/A	N/A	Details