The PPARs: from orphan receptors to drug discovery.

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Willson TM, Brown PJ, Sternbach DD, Henke BR

The PPARs: from orphan receptors to drug discovery.

J Med Chem. 2000 Feb 24;43(4):527-50.

PubMed ID
10691680 [ View in PubMed
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Abstract

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DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
{4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy}acetic acidPeroxisome proliferator-activated receptor deltaEC 50 (nM)530N/AN/ADetails
BezafibratePeroxisome proliferator-activated receptor alphaEC 50 (nM)50000N/AN/ADetails
BezafibratePeroxisome proliferator-activated receptor deltaEC 50 (nM)20000N/AN/ADetails
BezafibratePeroxisome proliferator-activated receptor gammaEC 50 (nM)60000N/AN/ADetails
ClofibratePeroxisome proliferator-activated receptor alphaEC 50 (nM)55000N/AN/ADetails
FenofibratePeroxisome proliferator-activated receptor alphaEC 50 (nM)30000N/AN/ADetails
PioglitazonePeroxisome proliferator-activated receptor gammaEC 50 (nM)580N/AN/ADetails
RosiglitazonePeroxisome proliferator-activated receptor gammaEC 50 (nM)43N/AN/ADetails
TroglitazonePeroxisome proliferator-activated receptor gammaEC 50 (nM)550N/AN/ADetails