Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis.

Article Details

Citation

Wagner CR, Benkovic SJ

Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis.

J Med Chem. 1992 Jul 24;35(15):2912-5.

PubMed ID
1495020 [ View in PubMed
]
Abstract

Not Available

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
PyrimethamineDihydrofolate reductaseKd (nM)13N/AN/ADetails
PyrimethamineDihydrofolate reductaseKi (nM)10N/AN/ADetails
PyrimethamineDihydrofolate reductaseKi (nM)20N/AN/ADetails
PyrimethamineDihydrofolate reductaseKd (nM)16N/AN/ADetails
PyrimethamineDihydrofolate reductaseKi (nM)2N/AN/ADetails
PyrimethamineDihydrofolate reductaseKi (nM)5.2N/AN/ADetails
PyrimethamineDihydrofolate reductaseKd (nM)1.4N/AN/ADetails
PyrimethamineDihydrofolate reductaseKi (nM)1.2N/AN/ADetails
PyrimethamineDihydrofolate reductaseKi (nM)0.19N/AN/ADetails
PyrimethamineDihydrofolate reductaseKd (nM)1.5N/AN/ADetails