Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.
Article Details
- CitationCopy to clipboard
Chen JB, Chern TR, Wei TT, Chen CC, Lin JH, Fang JM
Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.
J Med Chem. 2013 May 9;56(9):3645-55. doi: 10.1021/jm400179b. Epub 2013 Apr 22.
- PubMed ID
- 23570542 [ View in PubMed]
- Abstract
A series of dual-action compounds were designed to target histone deacetylase (HDAC) and 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) by having a hydroxamate group essential for chelation with the zinc ion in the active site of HDAC and the key structural elements of statin for binding with both proteins. In our study, the statin hydroxamic acids prepared by a fused strategy are most promising in cancer treatments. These compounds showed potent inhibitory activities against HDACs and HMGR with IC50 values in the nanomolar range. These compounds also effectively reduced the HMGR activity as well as promoted the acetylations of histone and tubulin in cancer cells, but were not toxic to normal cells.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Atorvastatin 3-hydroxy-3-methylglutaryl-coenzyme A reductase IC 50 (nM) 13 N/A N/A Details Lovastatin 3-hydroxy-3-methylglutaryl-coenzyme A reductase IC 50 (nM) 19800 N/A N/A Details Lovastatin 3-hydroxy-3-methylglutaryl-coenzyme A reductase IC 50 (nM) 30 N/A N/A Details Lovastatin Histone deacetylase 2 IC 50 (nM) 25933 N/A N/A Details Vorinostat Histone deacetylase 1 IC 50 (nM) 21 N/A N/A Details Vorinostat Histone deacetylase 2 IC 50 (nM) 101 N/A N/A Details Vorinostat Histone deacetylase 6 IC 50 (nM) 19 N/A N/A Details