Current and novel approaches to the drug treatment of schizophrenia.

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Rowley M, Bristow LJ, Hutson PH

Current and novel approaches to the drug treatment of schizophrenia.

J Med Chem. 2001 Feb 15;44(4):477-501.

PubMed ID

11170639 [ View in PubMed

]

Abstract

Not Available

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Clozapine	5-hydroxytryptamine receptor 1A	Ki (nM)	710	N/A	N/A	Details
Clozapine	5-hydroxytryptamine receptor 2A	Ki (nM)	4	N/A	N/A	Details
Clozapine	5-hydroxytryptamine receptor 2C	Ki (nM)	5	N/A	N/A	Details
Clozapine	Dopamine D1 receptor	Ki (nM)	53	N/A	N/A	Details
Clozapine	Dopamine D2 receptor	Ki (nM)	190	N/A	N/A	Details
Clozapine	Dopamine D3 receptor	Ki (nM)	280	N/A	N/A	Details
Clozapine	Dopamine D4 receptor	Ki (nM)	40	N/A	N/A	Details
Clozapine	Histamine H1 receptor	Ki (nM)	17	N/A	N/A	Details
Clozapine	Muscarinic acetylcholine receptor M1	Ki (nM)	0.98	N/A	N/A	Details
Olanzapine	5-hydroxytryptamine receptor 2A	Ki (nM)	1.9	N/A	N/A	Details
Olanzapine	5-hydroxytryptamine receptor 2C	Ki (nM)	2.8	N/A	N/A	Details
Olanzapine	Dopamine D1 receptor	Ki (nM)	10	N/A	N/A	Details
Olanzapine	Dopamine D2 receptor	Ki (nM)	2.1	N/A	N/A	Details
Olanzapine	Dopamine D3 receptor	Ki (nM)	49	N/A	N/A	Details
Olanzapine	Dopamine D4 receptor	Ki (nM)	28	N/A	N/A	Details
Olanzapine	Histamine H1 receptor	Ki (nM)	5.6	N/A	N/A	Details
Olanzapine	Muscarinic acetylcholine receptor M1	Ki (nM)	2.1	N/A	N/A	Details
Quetiapine	5-hydroxytryptamine receptor 1A	Ki (nM)	830	N/A	N/A	Details
Quetiapine	5-hydroxytryptamine receptor 2A	Ki (nM)	82	N/A	N/A	Details
Quetiapine	5-hydroxytryptamine receptor 2C	Ki (nM)	1500	N/A	N/A	Details
Quetiapine	Dopamine D1 receptor	Ki (nM)	390	N/A	N/A	Details
Quetiapine	Dopamine D2 receptor	Ki (nM)	69	N/A	N/A	Details
Quetiapine	Dopamine D3 receptor	Ki (nM)	340	N/A	N/A	Details
Quetiapine	Dopamine D4 receptor	Ki (nM)	1600	N/A	N/A	Details
Quetiapine	Histamine H1 receptor	Ki (nM)	21	N/A	N/A	Details
Quetiapine	Muscarinic acetylcholine receptor M1	Ki (nM)	56	N/A	N/A	Details
Ziprasidone	5-hydroxytryptamine receptor 1A	Ki (nM)	37	N/A	N/A	Details
Ziprasidone	5-hydroxytryptamine receptor 2A	Ki (nM)	0.25	N/A	N/A	Details
Ziprasidone	5-hydroxytryptamine receptor 2C	Ki (nM)	0.55	N/A	N/A	Details
Ziprasidone	Dopamine D1 receptor	Ki (nM)	9.5	N/A	N/A	Details
Ziprasidone	Dopamine D2 receptor	Ki (nM)	2.8	N/A	N/A	Details
Ziprasidone	Dopamine D3 receptor	Ki (nM)	10	N/A	N/A	Details
Ziprasidone	Dopamine D4 receptor	Ki (nM)	39	N/A	N/A	Details
Ziprasidone	Histamine H1 receptor	Ki (nM)	510	N/A	N/A	Details
Ziprasidone	Muscarinic acetylcholine receptor M1	Ki (nM)	>10000	N/A	N/A	Details