Selective optimization of side activities: another way for drug discovery.

Article Details

Citation

Wermuth CG

Selective optimization of side activities: another way for drug discovery.

J Med Chem. 2004 Mar 11;47(6):1303-14.

PubMed ID
14998318 [ View in PubMed
]
Abstract

Not Available

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
Clozapine5-hydroxytryptamine receptor 2AKi (nM)3.3N/AN/ADetails
Clozapine5-hydroxytryptamine receptor 2CKi (nM)13N/AN/ADetails
ClozapineDopamine D1 receptorKi (nM)540N/AN/ADetails
ClozapineDopamine D2 receptorKi (nM)150N/AN/ADetails
ClozapineDopamine D3 receptorKi (nM)360N/AN/ADetails
ClozapineDopamine D4 receptorKi (nM)40N/AN/ADetails
ClozapineHistamine H1 receptorKi (nM)2.1N/AN/ADetails
Haloperidol5-hydroxytryptamine receptor 2AKi (nM)25N/AN/ADetails
HaloperidolDopamine D1 receptorKi (nM)270N/AN/ADetails
HaloperidolDopamine D2 receptorKi (nM)1.4N/AN/ADetails
HaloperidolDopamine D3 receptorKi (nM)21N/AN/ADetails
MinaprineAcetylcholinesteraseIC 50 (nM)600000N/AN/ADetails
MinaprineMuscarinic acetylcholine receptor M1Ki (nM)17000N/AN/ADetails
Olanzapine5-hydroxytryptamine receptor 2AKi (nM)1.9N/AN/ADetails
Olanzapine5-hydroxytryptamine receptor 2CKi (nM)7.1N/AN/ADetails
OlanzapineDopamine D1 receptorKi (nM)250N/AN/ADetails
OlanzapineDopamine D2 receptorKi (nM)17N/AN/ADetails
OlanzapineDopamine D3 receptorKi (nM)54N/AN/ADetails
OlanzapineDopamine D4 receptorKi (nM)28N/AN/ADetails
OlanzapineHistamine H1 receptorKi (nM)3.5N/AN/ADetails
Quetiapine5-hydroxytryptamine receptor 2AKi (nM)120N/AN/ADetails
Quetiapine5-hydroxytryptamine receptor 2CKi (nM)3820N/AN/ADetails
QuetiapineDopamine D1 receptorKi (nM)4240N/AN/ADetails
QuetiapineDopamine D2 receptorKi (nM)310N/AN/ADetails
QuetiapineDopamine D3 receptorKi (nM)650N/AN/ADetails
QuetiapineDopamine D4 receptorKi (nM)1600N/AN/ADetails
QuetiapineHistamine H1 receptorKi (nM)19N/AN/ADetails
Sertindole5-hydroxytryptamine receptor 2AKi (nM)0.85N/AN/ADetails
Sertindole5-hydroxytryptamine receptor 2CKi (nM)1.3N/AN/ADetails
SertindoleDopamine D2 receptorKi (nM)7.4N/AN/ADetails
Ziprasidone5-hydroxytryptamine receptor 2AKi (nM)0.3N/AN/ADetails
Ziprasidone5-hydroxytryptamine receptor 2CKi (nM)13N/AN/ADetails
ZiprasidoneDopamine D1 receptorKi (nM)330N/AN/ADetails
ZiprasidoneDopamine D2 receptorKi (nM)9.7N/AN/ADetails
ZiprasidoneDopamine D3 receptorKi (nM)7.5N/AN/ADetails
ZiprasidoneDopamine D4 receptorKi (nM)39N/AN/ADetails
ZiprasidoneHistamine H1 receptorKi (nM)5.3N/AN/ADetails