Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.

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Pegoraro S, Lang M, Dreker T, Kraus J, Hamm S, Meere C, Feurle J, Tasler S, Prutting S, Kuras Z, Visan V, Grissmer S

Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304. doi: 10.1016/j.bmcl.2009.02.077. Epub 2009 Feb 25.

PubMed ID

19282171 [ View in PubMed

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Abstract

New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Clotrimazole	Intermediate conductance calcium-activated potassium channel protein 4	IC 50 (nM)	70	N/A	N/A	Details