Organosilicon molecules with medicinal applications.

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Franz AK, Wilson SO

Organosilicon molecules with medicinal applications.

J Med Chem. 2013 Jan 24;56(2):388-405. doi: 10.1021/jm3010114. Epub 2012 Nov 6.

PubMed ID

23061607 [ View in PubMed

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Abstract

The incorporation of silicon and synthesis of organosilicon small molecules provide unique opportunities for medicinal applications. The biological investigation of organosilicon small molecules is particularly interesting because of differences in their chemical properties that can contribute to enhanced potency and improved pharmacological attributes. Applications such as inhibitor design, imaging, drug release technology, and mapping inhibitor binding are discussed.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Venlafaxine	Sodium-dependent dopamine transporter	IC 50 (nM)	4430	N/A	N/A	Details
Venlafaxine	Sodium-dependent noradrenaline transporter	IC 50 (nM)	149	N/A	N/A	Details
Venlafaxine	Sodium-dependent serotonin transporter	IC 50 (nM)	20	N/A	N/A	Details