Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models.
Article Details
- CitationCopy to clipboard
Wang C, McFadyen IJ, Traynor JR, Mosberg HI
Design of a high affinity peptidomimetic opioid agonist from peptide pharmacophore models.
Bioorg Med Chem Lett. 1998 Oct 6;8(19):2685-8.
- PubMed ID
- 9873603 [ View in PubMed]
- Abstract
A pair of diastereomeric peptidomimetics based upon opioid receptor-binding pharmacophore models derived for a series of opioid tetrapeptides was synthesized. Both analogues display high opioid receptor affinity, moderate selectivity for the mu opioid receptor, and are potent, full agonists.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Fentanyl Kappa-type opioid receptor Ki (nM) 1130 N/A N/A Details Fentanyl Mu-type opioid receptor Ki (nM) 8.45 N/A N/A Details Morphine Kappa-type opioid receptor Ki (nM) 110 N/A N/A Details Morphine Mu-type opioid receptor Ki (nM) 6.51 N/A N/A Details