4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors.

Article Details

Citation

Hashimoto H, Maeda K, Ozawa K, Haruta J, Wakitani K

4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors.

Bioorg Med Chem Lett. 2002 Jan 7;12(1):65-8.

PubMed ID
11738574 [ View in PubMed
]
Abstract

A series of 4-aryl/cycloalkyl-5-phenyloxazole derivatives was synthesized and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1). These compounds were found to be potent and selective COX-2 inhibitors.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
IndomethacinProstaglandin G/H synthase 2IC 50 (nM)2400N/AN/ADetails