4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors.
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Hashimoto H, Maeda K, Ozawa K, Haruta J, Wakitani K
4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors.
Bioorg Med Chem Lett. 2002 Jan 7;12(1):65-8.
- PubMed ID
- 11738574 [ View in PubMed]
- Abstract
A series of 4-aryl/cycloalkyl-5-phenyloxazole derivatives was synthesized and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1). These compounds were found to be potent and selective COX-2 inhibitors.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Indomethacin Prostaglandin G/H synthase 2 IC 50 (nM) 2400 N/A N/A Details