Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.

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Vardanyan R, Vijay G, Nichol GS, Liu L, Kumarasinghe I, Davis P, Vanderah T, Porreca F, Lai J, Hruby VJ

Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.

Bioorg Med Chem. 2009 Jul 15;17(14):5044-53. doi: 10.1016/j.bmc.2009.05.065. Epub 2009 Jun 2.

PubMed ID

19540763 [ View in PubMed

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Abstract

Acids 9a-f as possible bivalent ligands designed as a structural combination of opioid mu-agonist (Fentanyl) and NSAID (Indomethacin) activities and produced compounds which were tested as analgesics. The obtained series of compounds exhibits low affinity and activity both at opioid receptors and as cyclooxygenase (COX) inhibitors. One explanation of the weak opioid activity could be stereochemical peculiarities of these bivalent compounds which differ significantly from the fentanyl skeleton. The absence of significant COX inhibitory properties could be explained by the required substitution of an acyl fragment in the indomethacin structure for 4-piperidyl.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Indomethacin	Prostaglandin G/H synthase 2	IC 50 (nM)	600	N/A	N/A	Details