Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.
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Pettipher R, Whittaker M
Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.
J Med Chem. 2012 Apr 12;55(7):2915-31. doi: 10.1021/jm2013997. Epub 2012 Feb 13.
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- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Indomethacin Prostaglandin D2 receptor 2 EC 50 (nM) 389 N/A N/A Details