Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric H+/K(+)-ATPase inhibitor.

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Yoon SH, Seo S, Lee Y, Hwang S, Kim DY

Syntheses of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]-benzothiazolidine derivatives as a potential gastric H+/K(+)-ATPase inhibitor.

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1909-12.

PubMed ID

9873457 [ View in PubMed

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Abstract

A series of 2-[(3,5-dimethyl-4-methoxypyridyl)alkyl]benzothiazolidine derivatives were synthesized and tested their inhibitory effects on gastric H+/K(+)-ATPase. Compound 4d exhibited potent in vitro inhibitory activity.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Omeprazole	Potassium-transporting ATPase alpha chain 1	IC 50 (nM)	3800	N/A	N/A	Details