Synthesis and pharmacological profile of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines.

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Yum EK, Kang SK, Kim SS, Choi JK, Cheon HG

Synthesis and pharmacological profile of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines.

Bioorg Med Chem Lett. 1999 Oct 4;9(19):2819-22.

PubMed ID

10522698 [ View in PubMed

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Abstract

A series of 1-aryl-3-substituted pyrrolo[3,2-c]quinolines were synthesized and evaluated for their anti-ulcer activity. While 3-substituents of pyrrolo[3,2-c]quinolines mostly affected the in vitro H+/K+ ATPase activity, 1-aryl substituents of pyrrolo[3,2-c]quinolines affected the in vivo gastric acid secretion. In addition, the compounds with good in vivo activity protected from ethanol-induced ulcer.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Omeprazole	Potassium-transporting ATPase alpha chain 1	IC 50 (nM)	22400	N/A	N/A	Details