Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.
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Pearlstein R, Vaz R, Rampe D
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.
J Med Chem. 2003 May 22;46(11):2017-22.
- PubMed ID
- 12747773 [ View in PubMed]
- Abstract
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DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Astemizole Histamine H1 receptor Ki (nM) 3 N/A N/A Details Astemizole Potassium voltage-gated channel subfamily H member 2 IC 50 (nM) 0.9 N/A N/A Details Cisapride 5-hydroxytryptamine receptor 4 Ki (nM) 29 N/A N/A Details Cisapride Potassium voltage-gated channel subfamily H member 2 IC 50 (nM) 47 N/A N/A Details Pimozide Dopamine D2 receptor Ki (nM) 12 N/A N/A Details Pimozide Potassium voltage-gated channel subfamily H member 2 IC 50 (nM) 18 N/A N/A Details Sertindole 5-hydroxytryptamine receptor 2A Ki (nM) 0.6 N/A N/A Details Sertindole Potassium voltage-gated channel subfamily H member 2 IC 50 (nM) 3 N/A N/A Details Terfenadine Histamine H1 receptor Ki (nM) 58 N/A N/A Details Terfenadine Potassium voltage-gated channel subfamily H member 2 IC 50 (nM) 56 N/A N/A Details Thioridazine Dopamine D2 receptor Ki (nM) 27 N/A N/A Details Thioridazine Potassium voltage-gated channel subfamily H member 2 IC 50 (nM) 191 N/A N/A Details