Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
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Hieble JP, Bondinell WE, Ruffolo RR Jr
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
J Med Chem. 1995 Sep 1;38(18):3415-44.
- PubMed ID
- 7658428 [ View in PubMed]
- Abstract
Not Available
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Alfuzosin Alpha-1A adrenergic receptor Ki (nM) 8.2 N/A N/A Details Alfuzosin Alpha-1B adrenergic receptor Ki (nM) 12 N/A N/A Details Alfuzosin Alpha-1B adrenergic receptor Ki (nM) 2.8 N/A N/A Details Alfuzosin Alpha-1D adrenergic receptor Ki (nM) 3.6 N/A N/A Details Doxazosin Alpha-1A adrenergic receptor Ki (nM) 2.6 N/A N/A Details Doxazosin Alpha-1D adrenergic receptor Ki (nM) 1.2 N/A N/A Details Prazosin Alpha-1A adrenergic receptor Ki (nM) 0.51 N/A N/A Details Prazosin Alpha-1B adrenergic receptor Ki (nM) 0.32 N/A N/A Details Prazosin Alpha-1D adrenergic receptor Ki (nM) 0.32 N/A N/A Details Prazosin Alpha-2A adrenergic receptor Ki (nM) 2133 N/A N/A Details Prazosin Alpha-2B adrenergic receptor Ki (nM) 365 N/A N/A Details Terazosin Alpha-1A adrenergic receptor Ki (nM) 7.3 N/A N/A Details Terazosin Alpha-1B adrenergic receptor Ki (nM) 30 N/A N/A Details Terazosin Alpha-1B adrenergic receptor Ki (nM) 2.2 N/A N/A Details Terazosin Alpha-1D adrenergic receptor Ki (nM) 3.5 N/A N/A Details