Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.
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Pouget C, Fagnere C, Basly JP, Habrioux G, Chulia AJ
Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.
Bioorg Med Chem Lett. 2002 Oct 21;12(20):2859-61.
- PubMed ID
- 12270163 [ View in PubMed]
- Abstract
Two 4-imidazolylflavans were synthesized and their relative stereochemistry was established by 1H and 13C NMR data. These compounds were tested for their activity to inhibit aromatase. It was observed that the introduction of an imidazolyl group at carbon 4 on flavan nucleus led to potent molecules.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Aminoglutethimide Cytochrome P450 19A1 IC 50 (nM) 5200 N/A N/A Details