Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.

Article Details

Citation

Pouget C, Fagnere C, Basly JP, Habrioux G, Chulia AJ

Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition.

Bioorg Med Chem Lett. 2002 Oct 21;12(20):2859-61.

PubMed ID
12270163 [ View in PubMed
]
Abstract

Two 4-imidazolylflavans were synthesized and their relative stereochemistry was established by 1H and 13C NMR data. These compounds were tested for their activity to inhibit aromatase. It was observed that the introduction of an imidazolyl group at carbon 4 on flavan nucleus led to potent molecules.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
AminoglutethimideCytochrome P450 19A1IC 50 (nM)5200N/AN/ADetails