Synthesis and characterization of azole isoflavone inhibitors of aromatase.

Article Details

Citation

Copy to clipboard

Hackett JC, Kim YW, Su B, Brueggemeier RW

Synthesis and characterization of azole isoflavone inhibitors of aromatase.

Bioorg Med Chem. 2005 Jun 2;13(12):4063-70. Epub 2005 Apr 25.

PubMed ID

15911319 [ View in PubMed

]

Abstract

The synthesis and biological evaluation of a series of 2-azole and 2-thioazole isoflavones as potential aromatase inhibitors are described. Differences in inhibitory activity of triazole and imidazole inhibitors are rationalized with density functional theory to expose a key difference in the electronic structure of these molecules. In addition, difference binding spectra of inhibitors to immunoaffinity-purified aromatase produces classical Type II spectra consistent with coordination of the nitrogen lone pair electrons to the aromatase P450 heme.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Aminoglutethimide	Cytochrome P450 19A1	Ki (nM)	1410	7	37	Details
Aminoglutethimide	Cytochrome P450 19A1	IC 50 (nM)	2800	7	37	Details