Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.
Article Details
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Lober S, Hubner H, Gmeiner P
Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.
Bioorg Med Chem Lett. 1999 Jan 4;9(1):97-102.
- PubMed ID
- 9990464 [ View in PubMed]
- Abstract
Piperazinylmethyl substituted pyrazolo[1,5-a]pyridines and related heterocycles were synthesized and found to recognize selectively the dopamine D4 receptor. For the most potent derivative 10d a Ki value of 2.0 nM was observed. SAR studies including the comparison of molecular isopotential surfaces were performed.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Clozapine Dopamine D3 receptor Ki (nM) 960 N/A N/A Details Clozapine Dopamine D4 receptor Ki (nM) 16 N/A N/A Details