Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.

Article Details

Citation

Lober S, Hubner H, Gmeiner P

Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.

Bioorg Med Chem Lett. 1999 Jan 4;9(1):97-102.

PubMed ID
9990464 [ View in PubMed
]
Abstract

Piperazinylmethyl substituted pyrazolo[1,5-a]pyridines and related heterocycles were synthesized and found to recognize selectively the dopamine D4 receptor. For the most potent derivative 10d a Ki value of 2.0 nM was observed. SAR studies including the comparison of molecular isopotential surfaces were performed.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
ClozapineDopamine D3 receptorKi (nM)960N/AN/ADetails
ClozapineDopamine D4 receptorKi (nM)16N/AN/ADetails