2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.

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Haubmann C, Hubner H, Gmeiner P

2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.

Bioorg Med Chem Lett. 1999 Jul 19;9(14):1969-72.

PubMed ID

10450964 [ View in PubMed

]

Abstract

The phenylpiperazinylmethyl substituted pyrrolylmethylenemalononitriles of type 3 and 4 were synthesized and evaluated as strong and selective dopamine D4 receptor ligands.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Clozapine	Dopamine D2 receptor	Ki (nM)	39	N/A	N/A	Details
Clozapine	Dopamine D2 receptor	Ki (nM)	28	N/A	N/A	Details
Clozapine	Dopamine D3 receptor	Ki (nM)	960	N/A	N/A	Details
Clozapine	Dopamine D4 receptor	Ki (nM)	16	N/A	N/A	Details