Enoximone in cardiac arrest caused by propranolol: two case reports.

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Sandroni C, Cavallaro F, Caricato A, Scapigliati A, Fenici P, Antonelli M

Enoximone in cardiac arrest caused by propranolol: two case reports.

Acta Anaesthesiol Scand. 2006 Jul;50(6):759-61.

PubMed ID

16987374 [ View in PubMed

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Abstract

We report two clinical cases of cardiac arrest, the former due to an adverse effect of intravenous (i.v.) propranolol in a patient with systemic sclerosis, the latter from a propranolol suicidal overdose. In both cases, conventional advanced life support (ALS) was ineffective but both patients eventually responded to the administration of enoximone, a phosphodiesterase III (PDE III) inhibitor. After the arrest, both patients regained consciousness and were discharged home. The chronotropic and inotropic effects of PDE III inhibitors are due to inhibition of intracellular PDEIII and are therefore unaffected by beta-blockers. These cases suggest that PDEIII inhibitors may be useful in restoring spontaneous circulation in cardiac arrest associated with beta-blocker administration when standard ALS is ineffective.

DrugBank Data that Cites this Article

Drugs

Enoximone

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Enoximone	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	Protein	Humans	Yes	Inhibitor	Details