Multi-target-directed ligands to combat neurodegenerative diseases.

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Cavalli A, Bolognesi ML, Minarini A, Rosini M, Tumiatti V, Recanatini M, Melchiorre C

Multi-target-directed ligands to combat neurodegenerative diseases.

J Med Chem. 2008 Feb 14;51(3):347-72. doi: 10.1021/jm7009364. Epub 2008 Jan 9.

PubMed ID
18181565 [ View in PubMed
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Abstract

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DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
DonepezilAcetylcholinesteraseIC 50 (nM)23N/AN/ADetails
FluoxetineSodium-dependent serotonin transporterIC 50 (nM)180N/AN/ADetails
RasagilineAmine oxidase [flavin-containing] BIC 50 (nM)4.4N/AN/ADetails
RivastigmineAcetylcholinesteraseIC 50 (nM)920N/AN/ADetails
SelegilineAmine oxidase [flavin-containing] AIC 50 (nM)1200N/AN/ADetails
SelegilineAmine oxidase [flavin-containing] BIC 50 (nM)7N/AN/ADetails
TacrineAcetylcholinesteraseIC 50 (nM)420N/AN/ADetails