Multi-target-directed ligands to combat neurodegenerative diseases.
Article Details
- CitationCopy to clipboard
Cavalli A, Bolognesi ML, Minarini A, Rosini M, Tumiatti V, Recanatini M, Melchiorre C
Multi-target-directed ligands to combat neurodegenerative diseases.
J Med Chem. 2008 Feb 14;51(3):347-72. doi: 10.1021/jm7009364. Epub 2008 Jan 9.
- PubMed ID
- 18181565 [ View in PubMed]
- Abstract
Not Available
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Donepezil Acetylcholinesterase IC 50 (nM) 23 N/A N/A Details Fluoxetine Sodium-dependent serotonin transporter IC 50 (nM) 180 N/A N/A Details Rasagiline Amine oxidase [flavin-containing] B IC 50 (nM) 4.4 N/A N/A Details Rivastigmine Acetylcholinesterase IC 50 (nM) 920 N/A N/A Details Selegiline Amine oxidase [flavin-containing] A IC 50 (nM) 1200 N/A N/A Details Selegiline Amine oxidase [flavin-containing] B IC 50 (nM) 7 N/A N/A Details Tacrine Acetylcholinesterase IC 50 (nM) 420 N/A N/A Details