Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line.

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Lee J, Nam BS, Kim H, Oh CH, Lee SH, Cho SJ, Sim TB, Hah JM, Kim DJ, Tae J, Yoo KH

Synthesis of aminoquinazoline derivatives and their antiproliferative activities against melanoma cell line.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5722-5. doi: 10.1016/j.bmcl.2010.08.010. Epub 2010 Aug 6.

PubMed ID

20797858 [ View in PubMed

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Abstract

The synthesis of a novel series of aminoquinazoline derivatives 1a-r and their antiproliferative activities against A375 human melanoma cell line were described. Among them, six compounds showed superior antiproliferative activities to Sorafenib as a reference compound. In particular, the representative compound 1q bearing chromen-4-one moiety exhibited excellent antiproliferative activity (IC(50)=0.006 muM) and good selectivity over HS27 fibroblast cell line.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Sorafenib	RAF proto-oncogene serine/threonine-protein kinase	IC 50 (nM)	6	N/A	N/A	Details