Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.
Article Details
- CitationCopy to clipboard
Mahindroo N, Wang CC, Liao CC, Huang CF, Lu IL, Lien TW, Peng YH, Huang WJ, Lin YT, Hsu MC, Lin CH, Tsai CH, Hsu JT, Chen X, Lyu PC, Chao YS, Wu SY, Hsieh HP
Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists: design, synthesis, structural biology, and molecular docking studies.
J Med Chem. 2006 Feb 9;49(3):1212-6.
- PubMed ID
- 16451087 [ View in PubMed]
- Abstract
A series of novel indole-based PPAR agonists is described leading to discovery of 10k, a highly potent PPAR pan-agonist. The structural biology and molecular docking studies revealed that the distances between the acidic group and the linker, when a ligand was complexed with PPARgamma protein, were important for the potent activity. The hydrophobic tail part of 10k makes intensive hydrophobic interaction with the PPARgamma protein resulting in potent activity.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID Peroxisome proliferator-activated receptor gamma P37231 Details - Binding Properties
Drug Target Property Measurement pH Temperature (°C) 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID Peroxisome proliferator-activated receptor gamma IC 50 (nM) 50 N/A N/A Details 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID Peroxisome proliferator-activated receptor gamma IC 50 (nM) 152 N/A N/A Details Rosiglitazone Peroxisome proliferator-activated receptor alpha IC 50 (nM) >10000 N/A N/A Details Rosiglitazone Peroxisome proliferator-activated receptor gamma IC 50 (nM) 92 N/A N/A Details