Differential activity of rosiglitazone enantiomers at PPAR gamma.
Article Details
- CitationCopy to clipboard
Parks DJ, Tomkinson NC, Villeneuve MS, Blanchard SG, Willson TM
Differential activity of rosiglitazone enantiomers at PPAR gamma.
Bioorg Med Chem Lett. 1998 Dec 15;8(24):3657-8.
- PubMed ID
- 9934490 [ View in PubMed]
- Abstract
Analysis of the enantiomers of rosiglitazone in a PPAR gamma binding assay suggests that the (S)-(-)-isomer is responsible for the antidiabetic activity.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Rosiglitazone Peroxisome proliferator-activated receptor gamma IC 50 (nM) 50 N/A N/A Details Rosiglitazone Peroxisome proliferator-activated receptor gamma IC 50 (nM) 2000 N/A N/A Details Rosiglitazone Peroxisome proliferator-activated receptor gamma IC 50 (nM) 60 N/A N/A Details Rosiglitazone Peroxisome proliferator-activated receptor gamma IC 50 (nM) 30 N/A N/A Details