Differential activity of rosiglitazone enantiomers at PPAR gamma.

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Parks DJ, Tomkinson NC, Villeneuve MS, Blanchard SG, Willson TM

Differential activity of rosiglitazone enantiomers at PPAR gamma.

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3657-8.

PubMed ID
9934490 [ View in PubMed
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Abstract

Analysis of the enantiomers of rosiglitazone in a PPAR gamma binding assay suggests that the (S)-(-)-isomer is responsible for the antidiabetic activity.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
RosiglitazonePeroxisome proliferator-activated receptor gammaIC 50 (nM)50N/AN/ADetails
RosiglitazonePeroxisome proliferator-activated receptor gammaIC 50 (nM)2000N/AN/ADetails
RosiglitazonePeroxisome proliferator-activated receptor gammaIC 50 (nM)60N/AN/ADetails
RosiglitazonePeroxisome proliferator-activated receptor gammaIC 50 (nM)30N/AN/ADetails