Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.

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Henke BR

Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.

J Med Chem. 2004 Aug 12;47(17):4118-27.

PubMed ID
15293980 [ View in PubMed
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Abstract

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DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
(2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACIDPeroxisome proliferator-activated receptor gammaEC 50 (nM)570N/AN/ADetails
(2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACIDPeroxisome proliferator-activated receptor gammaKi (nM)90N/AN/ADetails
(S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic AcidPeroxisome proliferator-activated receptor gammaEC 50 (nM)170N/AN/ADetails
BezafibratePeroxisome proliferator-activated receptor alphaEC 50 (nM)50000N/AN/ADetails
BezafibratePeroxisome proliferator-activated receptor gammaEC 50 (nM)60000N/AN/ADetails
ClofibratePeroxisome proliferator-activated receptor alphaEC 50 (nM)55000N/AN/ADetails
FenofibratePeroxisome proliferator-activated receptor alphaEC 50 (nM)30000N/AN/ADetails
RosiglitazonePeroxisome proliferator-activated receptor gammaKi (nM)50N/AN/ADetails
RosiglitazonePeroxisome proliferator-activated receptor gammaEC 50 (nM)40N/AN/ADetails
TesaglitazarPeroxisome proliferator-activated receptor alphaKi (nM)1000N/AN/ADetails
TesaglitazarPeroxisome proliferator-activated receptor alphaEC 50 (nM)1700N/AN/ADetails