Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.

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Huffman JW, Hepburn SA, Reggio PH, Hurst DP, Wiley JL, Martin BR

Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.

Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. doi: 10.1016/j.bmc.2010.06.054. Epub 2010 Jun 22.

PubMed ID

20621488 [ View in PubMed

]

Abstract

Three 1-methoxy analogs of CP-47,497 (7, 8, and 19) have been synthesized and their affinities for the cannabinoid CB(1) and CB(2) receptors have been determined. Although these compounds exhibit selectivity for the CB(2) receptor none have significant affinity for either receptor. Modeling and receptor docking studies were carried out, which provide a rationalization for the weak affinities of these compounds for either receptor.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Dronabinol	Cannabinoid receptor 2	Ki (nM)	36	N/A	N/A	Details